
Protein Kinase Inhibitors in Rheumatology Pages 13-27
Sebastián Herrera Uribe1 and Gloria Vásquez2
1Internal Medicine and Rheumatology Section, Universidad de Antioquia, Calle 7 AA No 30-241. Apto 701, Medellín, Antioquia, Colombia; 2Internal Medicine, Rheumatology Section, GICIG, Carrera 53 No 61-30. Laboratorio 410, Medellín, Antioquia, Colombia
DOI: http://dx.doi.org/10.12970/2310-9874.2014.02.01.4
Download PDFAbstract: Protein kinases have multiple roles in cell biology, many of which are deeply involved in inflammation and immunity. There are currently many treatment options for patients with autoimmune disease, but none that is completely effective. Protein kinase inhibitors are becoming one of the most promising therapeutic groups, not only for the treatment of disease, but for further developing our understanding of different pathologies. The purpose of this paper is to give an introduction to both protein kinases and their inhibitors, with their implications in the management of autoimmune diseases.
Keywords: Lupus erythematosus, protein kinases, phosphotransferases, Janus Kinase 3, protein kinases inhibitors, rheumatology, autoimmune diseases. Read more