Glucose Metabolism Disturbances in Colon Cancer (JEDM v2n2a11) - synergy - synergy

Glucose Metabolism Disturbances in Colon Cancer Pages 109-116

Agnieszka Sulich and Paweł Piątkiewicz

Department of Internal Medicine, 2nd Medical Faculty, Department of Internal Diseases, Diabetology and Endocrinology, of Warsaw Medical University, Warsaw, Poland

DOI: http://dx.doi.org/10.12970/2310-9971.2014.02.02.11

Abstract: Type 2 diabetes and cancer are currently the most common pathologies in human population. The constant increase in the number of new cases regarding both diseases is widely observed, while the prognosis for the nearest future is unfortunately very pessimistic. This article presents the pathophysiological connections between colon cancer and type 2 diabetes, with special focus on insulin resistance, hyperinsulinemia and insulin/IGF axis. Fatty tissues, especially visceral, despite energy supply are also a source of inflammatory cytokines, hormones and endopeptides which have a significant influence on cellular metabolism, hence leading to the development of particular neoplasms, like colon cancer.

Keywords: Colon cancer, insulin, hyperglycemia, diabetes. Read more

  • Why Choose Synergy

    Synergy Publishers opens a portal to researchers and scholarly communities We aspire to be one of the best publishers for professional and scholarly societies. We maintain a balanced, independent editorial policy being fully committed to authors with honesty. We strive to proceed in a manner that is conducive to a sustainable future.