Normal P Wave Dispersion in Colchicine-Resistant FMF Patients Pages 45-48

Naomi Nussinovitch1,4, Kivity Shaye2,4,5, Ilan Ben-Zvi2,3,4 and Avi Livneh2,3,4

1Hypertension Unit and Department of Internal Medicine D, Sheba Medical Center, Tel Hashomer, Israel; 2The Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, Israel; 3Department of Medicine F, Sheba Medical Center, Tel Hashomer, Israel; 4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 5The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2013, Sheba Medical Center, Tel-Hashomer, Israel

DOI: http://dx.doi.org/10.12970/2311-052X.2014.02.01.8

Abstract: Background: Cardiac involvement in familial Mediterranean fever (FMF) has been receiving increasing attention. P wave dispersion (Pd) is an electrocardiographic marker for supraventricular arrhythmias. It was recently reported that uncomplicated FMF is associated with normal Pd.

Aims: Our aim was to evaluate Pd and P wave duration in colchicine-resistant FMF patients, thus testing the effect of the continuously increased inflammatory burden on cardiac electrical stability of FMF patients.

Methods: Twenty two patients with colchicine-resistant FMF, and 22 age- and sex-matched control subjects were investigated. All participants underwent a 12-lead electrocardiography under strict standards. P wave length and P wave dispersion were computed from a randomly selected beat and an averaged beat constructed from 7-12 beats in a 10 second ECG.

Results: Minimal, maximal, and average P wave duration and P wave dispersion calculated from either a random beat or averaged beats, were similar in colchicine-resistant FMF patients and healthy individuals.

Conclusions: FMF patients, nonresponsive to colchicine treatment, but without amyloidosis, have normal atrial conduction parameters. Therefore, FMF, even in colchicine nonresponsive patients, does not seem to be associated with an increased risk for supraventricular arrhythmias.

Keywords: Familial Mediterranean fever (FMF), P wave dispersion, supraventricular arrhythmia, colchicine resistant FMF, chronic inflammation. Read more