Correlation of Fecal Calprotectin with Small Bowel MRI Findings in Crohn’s Disease Pages 12-17
Li Taina Sipponen1, Lauri Puustinen2 and Kirsti Numminen3
11Gastroenterology, University of Helsinki and Helsinki University Hospital, P.O.B. 340, Helsinki, Finland; 22Gastroenterology, University of Helsinki and Helsinki University Hospital P.O.B. 340, 00029 HUS, Helsinki, Finland; 33HUS Medical Imaging Center, Helsinki University Hospital, 00029 HUS, Helsinki, Finland
http://dx.doi.org/10.12970/2308-6483.2016.04.01.4
Abstract: Objective: In Crohn’s disease, correlation of fecal neutrophil-derived biomarker calprotectin with small bowel magnet resonance enteroclysis (MRE) is scarcely studied.
Methods: 51 consecutive Crohn’s disease patients undergoing MRE and having a measured fecal calprotectin at the time of the MRE were retrospectively studied. MRE findings were scored by an experienced radiologist according to a ranking taking into account 15 MRE variables. Furthermore, radiologist assessed the MRE findings as active, inactive or normal.
Results: Median fecal calprotectin in patients with active ileal inflammation was significantly higher (281 μg/g, interquartil range IQR 66-574) than in those without signs of active inflammation in MRE (83 μg/g, IQR 48-245 p =0.0435). Fecal calprotectin correlated significantly with bowel wall thickening and enhancement detected in MRE. Using receiver operator characteristic curve, the highest sum for sensitivity (60%) and specificity (76%) was achieved at calprotectin concentration 213 μg/g to detect active Crohn’s disease.
Conclusion: Fecal calprotectin correlates significantly with signs of active Crohn’s disease in MRE and is significantly higher among patients with active inflammatory MRE finding than in those without signs of active inflammation.
Keywords: Fecal markers, Crohn’s disease activity, MRI enteroclysis, MRI enterography. Read more
