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The Glucose Metabolism in Metabolic Syndrome Patients with Non-Alcoholic Fatty Liver Disease (GJGH v2n1a4) - synergy - synergy

The Glucose Metabolism in Metabolic Syndrome Patients with Non-Alcoholic Fatty Liver Disease Pages 19-28

Tao Wu1,2, Hai-Yan Song1, Hua-Feng Wei1, Ming Yang1, Song-Hua He1 and Guang Ji1

1Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; 2Center of Chinese Medicine Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

http://dx.doi.org/10.12970/2308-6483.2014.02.01.4

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Abstract: Aim: To explore the association between NAFLD and MetS, and to clarify the difference of glucose metabolism between MetS with and without NAFLD.

Methods: In this paper, we explore the association between NAFLD and MetS from the viewpoint of clinical characters and discuss the difference of abnormal glucose metabolism in the etiology of NAFLD and MetS, which based on metabolic profiling of urinary carbohydrates using gas chromatography/mass spectrometry (GC/MS) and multivariate statistical analysis with Model Population Analysis (MPA) based Support Vector Machines (SVMs).

Results: The BMI, waist circumference, hip circumference, WHR and diastolic blood pressure in MetS patients with NAFLD were significantly higher than patients without NAFLD (P<0.001 or P<0.05). The incorporative obese and hyperlipidemia were significantly higher in MetS patients with NAFLD compared with those without NAFLD (P<0.001 and P<0.05). The biochemical analysis indicated that triglyceride and glycated hemoglobin were significantly higher in MetS patients with NAFLD (P<0.05). Other significant differences were not found in fasting glucose, post-load glucose, HDL-C, ALT and VLDL-C between the two groups (P>0.05). Consequently, two potential biomarkers, Glucose and Inositol A, were discovered in the two groups using MPA/SVM and kruskal-Wallis test.

Conclusion: This research shows the incidence of abdominal obese and hyperlipidemia to be significantly higher in MetS patients with NAFLD than that observed in those without NAFLD. Moreover, the higher glycated hemoglobin in MetS patients with NAFLD suggests the poorer abnormal glucose metabolism. Furthermore, according the GC/MS combined with MPA/SVM, the two groups could be separated apparently from the glucose data, and two differential metabolites including Glucose and Inositol A are found.

Keywords: Glucose metabolism, metabolic syndrome, non-alcoholic fatty liver disease, Support Vector Machines. Read more →

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