Prevalence of Antibiotic Resistance and Minimum Inhibitory Concentrations of Helicobacter pylori Isolates from Clinical Gastritis Patients, Saudi Arabia (GJGH v1n2a6) - synergy - synergy

Prevalence of Antibiotic Resistance and Minimum Inhibitory Concentrations of Helicobacter pylori Isolates from Clinical Gastritis Patients, Saudi Arabia Pages 101-106

Amer Ibrahim Al-Omar1,2, Maripandi Arjunan1,3 and Ali A. Al-Salamah1

1Unit of Medical Bacteriology, Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, Saudi Arabia; 2Health Science Colleges, P.O. Box 3761, Dammam 31481, Saudi Arabia; 3Department of Microbiology, Government Arts College for Men, Krishnagiri, Tamilnadu, India

http://dx.doi.org/10.12970/2308-6483.2013.01.02.6

Download PDF

Abstract: Background: Establishing effective and acceptable treatment regimens for patients infected with Helicobacter pylori continues to pose problems for physician and patient alike in Saudi Arabia. The aim of the study was to assess the antibiotics resistance and to find out the MICs of the drugs which are commonly used against H. Pylori.

Methods: A total of one hundred antral biopsy specimens were collected and processed from which seventy-six strains of H. pylori were isolated. All the isolates were performed antibiotics sensitivity and E-test.

Results: The antibiotics result revealed that of H. pylori isolates 72% strains were resistant to metronidazole and 8% of isolates were resistant to clarithromycin. On the basis of antibiotics resistant a five different antibiotics phenotypes were found among H. pylori isolates. The distribution of metronidazole MICs was high in the range between 32 to128 mg/L. However all other antibiotics showed the effective MICs range was below 1 mg/L.

Conclusions: Our findings suggested that resistance to metronidazole has been increasing in the Saudi population. The resistance may be linked to the frequentuse of these antimicrobial agents for treating parasitic infections. The E test results revealed that the most effective antibiotic MICs were amoxicillin and clarithromycin against H. Pylori infection.

Keywords: Peptic ulcer, Helicobacter pylori, Antral biopsy, Antibiotics, Resistance. Read more

  • Why Choose Synergy

    Synergy Publishers opens a portal to researchers and scholarly communities We aspire to be one of the best publishers for professional and scholarly societies. We maintain a balanced, independent editorial policy being fully committed to authors with honesty. We strive to proceed in a manner that is conducive to a sustainable future.