Effect of Robot-Assisted Treadmill Training on Motor Functions Depending on Severity of Impairment in Patients with Bilateral Spastic Cerebral Palsy 

Authors

  • Stanislava Klobucká Rehabilitation Centre Harmony, Bratislava, Slovakia
  • Michal Kováč Clinic of Neurology, Faculty Hospital, Nové Zámky, Slovakia
  • Elena Žiaková Rehabilitation Centre Harmony, Bratislava, Slovakia
  • Robert Klobucký Slovak Academy of Sciences, Institute for Sociology, Bratislava, Slovakia

DOI:

https://doi.org/10.12970/2308-8354.2013.01.02.1

Keywords:

 Gout, urate crystals, methods of not-staining, polarizing microscope.

Abstract

 Objective: To assess impact of RATT (robot-assisted treadmill training) on motor function in patients with cerebral palsy depending on the severity of motor impairment. Design: Uncontrolled prospective pilot study with pre-post treatment outcome comparison according to severity of motor impairment. Setting: Outpatient Rehabilitation Centre. Participants: Fifty-one patients aged 4 - 27 years with bilateral spastic cerebral palsy. Interventions: Patients were divided into two groups according to severity of motor impairment determined by the Gross Motor Function Classification Scale (GMFCS). All 51 participants underwent 20 RATT sessions over a 5-6 week period in an outpatient approach using the Lokomat® driven gait orthosis (DGO). Outcome Measures: Dimension A(lying, rolling), B(sitting), C(crawling, kneeling), D (standing) and E(walking, running, jumping) within the Gross Motor Function Measure (GMFM-88), 6-minute walking test, 10-meter walk test, Functional Ambulation Categories (FAC). Results: Patients demonstrated statistically significant improvements in all GMFM-88 dimensions. Improvements in GMFM A, B and C were significantly larger in the more severely affected cohort (GMFCS III, IV) compared to the mildly affected cohort (GMFCS I, II). In contrast, GMFM D and E improvements were greater in the mildly affected cohort, but not statistically significant. Mean (SD) maximum gait speed of 0.75 (0.48) to 0.89 (0.52) m/s; mean (SD) 6 Min WT of 154 (103.21) to 191.21 (114.55) m; as well as the mean (SD) FAC of 1.44 (1.22) to 1.89 (1.33) showed a statistically significant level of improvement (p= .000). Conclusion: RATT is a promising treatment option in ambulatory and non-ambulatory patients with cerebral palsy. The severity of motor impairment affects the amount of improvement that can be achieved. Keywords: Robot-assisted treadmill training, cerebral palsy, gross motor function measure, impairment, neurodevelopmental concept.

References


[1] Cazalets JR, Borde M, Clarac F. Localization and Organization of the Central Pattern Generator for Hind limb Locomotion in Newborn Rat. J Neurosci 1995; 15: 4943-51.
[2] Duysens J, Van de Crommert H. Neural control of locomotion, Part 1: The central pattern generator from cats to humans. Gait Posture 1998; 7: 131-41. http://dx.doi.org/10.1016/S0966-6362(97)00042-8
[3] Mac Kay-Lyons M. Central pattern generation of locomotion: a review of evidence. Phys Ther 2002; 82: 69-83.
[4] Borggraefe I, Schaefer JS, Klaiber M, Dabrowski E, et al. Robotic- assisted treadmill therapy improves walking and standing performance in children and adolescents with cerebral palsy. Eur J Pediatr Neurol 2010; 14: 496-502. http://dx.doi.org/10.1016/j.ejpn.2010.01.002
[5] Borggraefe I, Meyer-Heim A. Kumar A, Schaefer JS, Berweck S, Heinen F. Improved gait parameters after robotic- assisted locomotor treadmill therapy in a 6-year-old child with cerebral palsy. Movement Disord 2008; 23: 280-3. http://dx.doi.org/10.1002/mds.21802
[6] Dietz V, Müller R, Colombo G. Locomotor activity in spinal man: significance of afferent input from joint and load receptors. Brain 2002; 125: 2626-34. http://dx.doi.org/10.1093/brain/awf273
[7] Kokavec M, iaková E. Developmental dysplasia of the hip. Diagnosis and treatment based upon the developmental kinesiology principles. Bratislava: Herba 2008.
[8] Vojta V. Die zerebralen Bewegungsstörungen im Säuglingsalter, Ferdinand Enke Verlag, Stuttgart 1988.
[9] Meyer-Heim A, Borggraefe I, Ammann-Reiffer C, et al. Feasibility of robotic assisted locomotor training in children with central gait impairment. Dev Med Child Neurol 2007; 49: 900-6. http://dx.doi.org/10.1111/j.1469-8749.2007.00900.x
[10] Mayr A, Kofler M, Quirbach E, Matzak H, Frhlich K, Saltuari L. Prospective, blinded, randomized crossover study of gait rehabilitation in stroke patients using the lokomat gait orthosis. Neurorehabil Neural Repair 2007; 21: 307-14. http://dx.doi.org/10.1177/1545968307300697
[11] Wirtz M, Zemon DH, Rupp R, et al. Effectiveness of automated locomotor training in patients with chronic incomplete spinal cord injury: a multicenter trial. Arch Phys Med Rehabil 2005; 86: 672-80. http://dx.doi.org/10.1016/j.apmr.2004.08.004
[12] Hornby TG, Zemon DH, Campbell D. Robotic assisted, bodyweight-supported treadmill training in individuals following motor incomplete spinal cord injury. Phys Ther 2005; 85: 52- 66.
[13] Meyer- Heim A, Ammann-Reiffer C, Schmartz A, et al. Improvement of walking abilities after robotic- assisted locomotion training in children with cerebral palsy. Arch Dis Child 2009; 94: 615-20. http://dx.doi.org/10.1136/adc.2008.145458
[14] Westlake KP, Patten C. Pilot study of Lokomat versus manual-assisted treadmill training for locomotor recovery post–stroke. J Neuroeng Rehabil 2009; 6: 1. http://dx.doi.org/10.1186/1743-0003-6-18
[15] Husemann B, Müller F, Krewer C, Heller S, Koenig E. Effects of locomotion training with assistance of robot-driven gait orthosis in hemiparetic patients after stroke. Stroke 2007; 38: 349-54. http://dx.doi.org/10.1161/01.STR.0000254607.48765.cb
[16] Beer S, Aschbacher B, Manoglou D, Gamper E, Kool J, Kesselring J. Robot-assisted gait training in multiple sclerosis: a pilot randomized trial. Mult Scler 2008; 14: 231-6. http://dx.doi.org/10.1177/1352458507082358
[17] Lo AC, Triche EW. Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil Neural Repair 2008; 22: 661-71. http://dx.doi.org/10.1177/1545968308318473
[18] Ustinova K, Chernikova L, Bilimenko A, Telenkov A, Epstein N. Effect of robotic locomotor training in an individual with Parkinson's disease: a case report. Disabil Rehabil Assist Technol 2011; 6: 77-85. http://dx.doi.org/10.3109/17483107.2010.507856
[19] Borggraefe I, Kiwull L, Schaefer JS, Koerte I, et al. Sustainability of motor performance after robotic-assisted treadmill therapy in children: an open, non randomized baseline- treatment study. Eur J Phys Rehabil Med 2010; 46: 125-31.
[20] Palisano R, Rosenbaum P, Walter S, Russell D, Wood E, Galuppi B. Development and reliabilityof a system to classifygrossmotor function in childrenwithcerebralpalsy. Dev Med Child Neurol 1997; 39: 214-23. http://dx.doi.org/10.1111/j.1469-8749.1997.tb07414.x
[21] Russell DJ, Rosenbaum PL, Cadman DT, et al. The gross motor function measure: A means to evaluate the effects of physical therapy. Dev Med Child Neurol 1989; 31: 341-52. http://dx.doi.org/10.1111/j.1469-8749.1989.tb04003.x
[22] Russell DJ, Rosenbaum PL, Avery LM, Lane M. Gross Motor Function Measure (GMFM-66 & GMFM-88) User’s Manual. Clinics in Developmental Medicine No. 159. London: Mac Keith Press 2002.
[23] Provost B, Dieruf K, Burtner PA, et al. Endurance and gait in children with cerebral palsy after intensive body weight – supported treadmill training. Pediatr Phys Ther 2007; 19: 2- 10. http://dx.doi.org/10.1097/01.pep.0000249418.25913.a3
[24] Thompson P, Beath T, Bell J, et al. Test–retest reliability of the 10-metre fast walktest and 6-minute walk test in ambulatory school-aged children with cerebral palsy. Dev Med Child Neurol 2008; 50: 370-6. http://dx.doi.org/10.1111/j.1469-8749.2008.02048.x
[25] Holden MK, Gill KM, Magliozzi MR, et al. Clinical gait assessment in the neurologically: reliability and meaningfulness. Phys Ther 1984; 64: 35-40.
[26] Schindl MR, Forstner C, Kern H, Hesse S. Treadmill training with partial body weight support in nonambulantory patients with cerebral palsy. Arch Phys Med Rehabil 2000; 81: 301-6. http://dx.doi.org/10.1016/S0003-9993(00)90075-3
[27] Cherng RJ, Liu CF, Lau TW, Hong RB. Effect of treadmill training with body weight support on gait and gross motorfunction in children with spastic cerebral palsy. Am J Phys Med Rehabil 2007; 86: 548-55. http://dx.doi.org/10.1097/PHM.0b013e31806dc302
[28] Knox V, Evans, AL. Evaluation of the functional effects of a course of Bobath therapy in children with cerebral palsy: a preliminary study. Dev Med Child Neurol 2002; 44: 447-60. http://dx.doi.org/10.1111/j.1469-8749.2002.tb00306.x
[29] Wang H, Yang Y. Evaluation the responsiveness of 2 versions of the gross motor function measure for children with cerebral palsy. Arch Phys Med Rehabil 2006; 87: 51-6. http://dx.doi.org/10.1016/j.apmr.2005.08.117
[30] Patritti B, Sicari M, Deming M. Enhancement and retention of locomotor function in children with cerebral palsy after robotic gait training. Gait Posture 2011; 30: S9-S10. http://dx.doi.org/10.1016/j.gaitpost.2009.08.017
[31] Montinaro A, Piccinini L, Romei M, et al. Robotic-assisted locomotion training in children affected by cerebral palsy. Gait Posture 2011; 33: S55-S56. http://dx.doi.org/10.1016/j.gaitpost.2010.10.068
[32] Day JA, Fox EJ, Lowe J, Swales HB, Behrman AL. Locomotor training with partial body weight support on a treadmill in a nonambulatory child with spastic tetraplegic cerebral palsy: a case report. Pediatr Phys Ther 2004; 16: 106-13. http://dx.doi.org/10.1097/01.PEP.0000127569.83372.C8
[33] Begnoche DM, Pitetti KH. Effects of traditional treatment and partial body weight treadmill training on the motor skills of children with spastic cerebral palsy: a pilot study. Pediatr Phys Ther 2007; 19: 11-9. http://dx.doi.org/10.1097/01.pep.0000250023.06672.b6
[34] Mattern-Baxter K. Effects of partial body weight supported treadmill training on children with cerebral palsy. Pediatr Phys Ther 2009; 21: 12-22. http://dx.doi.org/10.1097/PEP.0b013e318196ef42
[35] Hanna SE, Bartlett DJ, Rivard LM, Russel DJ. Reference curves for the gross motor function measure: percentiles for clinical description and tracking over time among children with cerebral palsy. Phys Ther 2008; 88: 596-607. http://dx.doi.org/10.2522/ptj.20070314
[36] Beckung E, Carlsson G, Carlsdotter S, Uvebrant P. The natural history of gross motor development in children with cerebral palsy aged 1 to 15 years. Dev Med Child Neurol 2007; 49: 751-6. http://dx.doi.org/10.1111/j.1469-8749.2007.00751.x
[37] Sicari M, Patritti B, Deming LC, et al. Robotic gait training in children with cerebral palsy: A case series. Gait Posture 2011; 30: S2. http://dx.doi.org/10.1016/j.gaitpost.2009.07.077
[38] Dodd KJ, Foley S. Partial body-weight-supported treadmill training can improve walking in children with cerebral palsy: a clinical controlled trial. Dev Med Child Neurol 2007; 49: 101- 5. http://dx.doi.org/10.1111/j.1469-8749.2007.00101.x
[39] Borggraefe I, Klaiber M, Schuler T, Warken B, et al. Safety of robotic- assisted treadmill therapy in children and adolescents with gait impairment: a bi-centre survey. Dev Neurorehabil 2010; 13: 114-9. http://dx.doi.org/10.3109/17518420903321767
[40] Koenig A, Brütsch K, Zimmerli L, Guidali M, Duschau-Wicke A. Virtual environments increase participation of children with cerebral palsy in robot-aided treadmill training. Virtual Rehabil 2008; 121-6.

Downloads

Published

2013-02-02

Issue

Section

Articles