Polycystic ovarian disease, Metabolic syndrome, insulin resistance, and roidobesity.
Abstract
Polycystic ovarian disease (PCOS) is the most common endocrine disorder among women in genital activity (prevalence: 5 and 10%). It is a frequent cause of hirsutism and infertility in women and affects 3-10% of women overall population. Whatever the age of onset, PCOS predisposes to metabolic and early cardiovascular complications. The PCOS is frequently associated with obesity, insulin resistance and hyperinsulinemia. There is a greater risk of glucose intolerance, diabetes mellitus (10%) and hyperlipidemia (more than half of women). The aim of our study was to report the frequency of metabolic syndrome (MS) in PCOS and specify its clinical and biological characteristics. This is a prospective, descriptive study which concerned 66 primary PCOS patients. The frequency of metabolic syndrome was 48.5%. The average age was 33.9 ± 9.22 years (16 – 45) Just under half of the patients (42.4%) were obese at diagnosis. The mean BMI was 32.4 kg / m2 ± 0.3. A slightly more than 2/3 of PCOS patients (72.6%) have a and roidobesity. The average waist circumference PCOS patients was 87.5 ± 0.1 cm. Nearly a third of patients have abnormal glucose tolerance. They have an average triglycerides, mean arterial pressure, mean blood glucose, insulin and an average index HOMA significantly higher (p: 10- 3). Their HDL level is significantly reduced (p <10-3). A little over a quarter of PCOS patients with metabolic syndrome: 37.5%) have all of the risk factors for MS at diagnosis.
