Khadija Diyane, Ghizlane El Mghari and Nawal El Ansari Department of Endocrinology, Ibn Tofaïl Hospital. PCIM Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Rue el Mostachfa, Gueliz, 40 000, Marrakech, Maroc
Wolfram Syndrome (WFS) is a rare autosomal recessive disease. It is a progressive neurodegenerative disorder in which patients present with diabetes mellitus, optic atrophy, diabetes insipidus, sensorineural deafness, urologic abnormalities and multiple neurological abnormalities. This study reports two sisters with late diagnosed wolfram syndrome with diabetes insipidus, diabetes mellitus, optic atrophy, deafness and urological abnormalities. The condition should be evaluated in a multidisciplinary attitude and specific tests are necessary to make a precise diagnosis of the syndrome.
