Uric Acid Association with the Metabolic Syndrome and Type 2 Diabetes
DOI:
https://doi.org/10.12970/2310-9971.2018.06.01Keywords:
Serum uric acid, Type 2 diabetes, Metabolic syndrome, Pre-diabetes.Abstract
Introduction and Objectives: The metabolic syndrome (MetS) consists of a group of cardiovascular risk factors, highly prevalent worldwide, afflicting an estimated 20 to 25% of the world’s population. There is a probable relationship between serum uric acid (SUA), Type 2 diabetes (T2D) and the MetS but the literature presents conflicting data. Our primary objective was to assess any association between SUA, T2D, MetS, the lipid profile and pre-diabetes (PD).References
[1] American Diabetes. Standards of medical care in diabetes. Diabetes Care 2014; 37(Suppl 1): S14-80. https://doi.org/10.2337/dc14-S014
[2] American Heart Association. About Pre-diabetes. Consulted on April 20th, 2014 and available on www.heart.org/ HEARTORG/Conditions/Diabetes/AboutDiabetes/About-Prediabetes_UCM_461494_Article.jsp
[3] Alberti KG, Zimmet P, Shaw J. The metabolic syndrome-a new worldwide definition. Lancet 2005; 366(9491): 1059- 1062. https://doi.org/10.1016/S0140-6736(05)67402-8
[4] American Heart Association. Understanding blood pressure readings. Consulted on November 20th 2014 and available on http://www.heart.org/HEARTORG/Conditions/HighBloodPres sure/AboutHighBloodPressure/Understanding-BloodPressure-Readings_UCM_301764_Article.jsp
[5] Bandaru P, Shankar A. Association between serum uric acid levels and diabetes mellitus. International Journal of Endocrinology 2011. https://doi.org/10.1155/2011/604715
[6] Yu KH, See L-C, Huang Y-C, Yang C-H, et al. Dietary Factors Associated with Hyperuricemia in Adults. Seminars in Arthritis and Rheumatism 2008; 37(4): 243-250. https://doi.org/10.1016/j.semarthrit.2007.04.007
[7] Kakafika A, Tsimihodimos V, Elisaf M. Effect of atorvastatin on serum uric acid levels. Atherosclerosis 2001; 158(1): 255. https://doi.org/10.1016/S0021-9150(01)00567-6
[8] Gibson T, Rodgers AV, Simmonds HA, Court-Brown F, et al. A controlled study of diet in patients with gout. Annals of the Rheumatic Diseases 1983; 42(2): 123-127. https://doi.org/10.1136/ard.42.2.123
[9] Takahashi MM, De Oliveira EP, De Carvalho AL, Dantas LA, et al. Metabolic Syndrome and dietary components are associated with coronary artery disease risk score in freeliving adults: a cross-sectional study. Diabetol Metab Syndr 2011; 3: 7-10. https://doi.org/10.1186/1758-5996-3-7
[10] Chen JH, Chuang SY, Chen HJ, Yeh WT, et al. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum 2009; 61: 225-232. https://doi.org/10.1002/art.24164
[11] Ruggiero C, Cherubini A, Ble A, Bos AJ, et al. Uric acid and inflammatory markers. Eur Heart J 2006; 27: 1174-1181. https://doi.org/10.1093/eurheartj/ehi879
[12] Yoo TW, Sung KC, Shin HS, Kim BJ, et al. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Biochem Biophys Res Commun 2014; 447(4): 707-14.
[13] Zhu Y, Hu Y, Huang T, Zhang Y, et al. High uric acid directly inhibits insulin signaling and induces insulin resistance. Biochem Biophys Res Commun 2014; 447(4): 707-14. https://doi.org/10.1016/j.bbrc.2014.04.080
[14] Krishnan E, Pandya BJ, Chung L, Hariri A, et al. Hyperuricemia in young adults and risk of insulin resistance, prediabetes and diabetes: a 15- year follow-up study. American Journal of Epidemilogy 2012; 176(2): 108-116. https://doi.org/10.1093/aje/kws002
[15] Lv Q, Meng X-F, He F-F, Chen S, et al. High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. Plos One 2013; 8(2). https://doi.org/10.1371/journal.pone.0056864
[16] Kodama S, Saito K, Yachi Y, Asumi M, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care 2012; 32(9): 1737-1742. https://doi.org/10.2337/dc09-0288
[17] Nan H, Pang Z, Wang S, Gao W, et al. Serum uric acid, plasma glucose and diabetes. Diabetes and Vascular Disease Research 2010; 7(1): 40-46. https://doi.org/10.1177/1479164109347408
[18] Bhole V, Choi JWJ, Woo Kim S, de Vera M, et al. Serum Uric Acid Levels and the Risk of Type 2 Diabetes: A Prospective Study. The American Journal of Medicine 2010; 123(10): 957-961. https://doi.org/10.1016/j.amjmed.2010.03.027
[19] Matsuura F, Yamashita S, Nakamura T, Nishida M, et al. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metabolism 1998; 47(8): 929-933. https://doi.org/10.1016/S0026-0495(98)90346-8
[20] Lin S-D, Tsai D-H, Hsu S-R. Association Between Serum Uric Acid Level and Components of the Metabolic Syndrome. Journal of the Chinese Medical Association 2006; 69(11): 512-516. https://doi.org/10.1016/S1726-4901(09)70320-X
[21] Madani MK, Abdrabo AA. Association between serum uric acid and selected components of metabolic syndrome. Laboratory Medicine Journal 2013; 1(1): 23-29.
[22] Liu P-W, Chang T-Y, Chen J-D. Serum uric acid and metabolic syndrome in Taiwanese adults. Metabolism 2010; 59(6): 802-807. https://doi.org/10.1016/j.metabol.2009.09.027
[23] Lohsoonthorn V, Dhanamun B, Williams MA. Prevalence of Hyperuricemia and its Relationship with Metabolic Syndrome in Thai Adults Receiving Annual Health Exams. Archives of Medical Research 2006; 37(7): 883-889. https://doi.org/10.1016/j.arcmed.2006.03.008
[24] Lin C-S, Lee W-L, Hung Y-J, Lee D-Y, et al. Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan. International Journal of Cardiology 2012; 156 (1): 41-46. https://doi.org/10.1016/j.ijcard.2010.10.033
[25] Milionis HJ, Nikas S, Elisaf MS. Effects of losartan/diuretic combination treatment on serum uric acid levels in hypertensive patients. The American Journal of Cardiology 2001; 88(9): 1084. https://doi.org/10.1016/S0002-9149(01)01959-2
[26] Yang T, Chu C-H, Bai C-H, You S-L, et al. Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study. Atherosclerosis 2012; 220(2): 525-531. https://doi.org/10.1016/j.atherosclerosis.2011.11.014
[27] De Olivera EP, Burini RC. High plasma uric acid concentration: causes and consequences. Diabetology & Metabolic Syndrome 2012; 4(12). https://doi.org/10.1186/1758-5996-4-12
[28] Wei SH, Lin JD, Hsu CH, Wu CZ, et al. Higher uric acid is associated with higher rate of metabolic syndrome in Chinese elderly. European Geriatric Medicine 2014; 5(1): 26- 30. https://doi.org/10.1016/j.eurger.2013.10.006
[29] Jia Z, Zhang X, Kang S, Wu Y. Serum uric acid levels and incidence of impaired fasting glucose and type 2 diabetes mellitus: A meta-analysis of cohort studies. Diabetes Research and Clinical Practice 2013; 101(1): 88-96. https://doi.org/10.1016/j.diabres.2013.03.026
[30] Yamada T, Fukatsu M, Suzuki S, Wada T, et al. Elevated serum uric acid predicts impaired fasting glucose and type 2 diabetes only among Japanese women undergoing health checkups. Diabetes & Metabolism 2011; 37(3): 252-258. https://doi.org/10.1016/j.diabet.2010.10.009
[31] Gul OO, Ersoy C, Gul B, Cander S, Unal O, Erturk E, Imamoglu S. Does uric acid predict insulin resistance in polycystic ovary syndrome? 2011. Consulted on November 17th 2014 and available on http://www.endocrineabstracts.org/ea/0026/ea0026p114.htm
[32] Liou T-L, Lin M-W, Hsiao L-C, Tsai T-T, et al. Is Hyperuricemia: Another Facet of the Metabolic Syndrome? Journal of the Chinese Medical Association 2006; 69(3): 104- 109. https://doi.org/10.1016/S1726-4901(09)70186-8
[33] Hara S, Tsuji H, Ohmoto Y, Amakawa K, et al. High serum uric acid level and low urine pH as predictors of metabolic syndrome: a retrospective cohort study in a Japanese urban population. Metabolism 2012; 61(2): 281-288. https://doi.org/10.1016/j.metabol.2011.06.026
[34] Choi JW, Ford ES, Gao X, Choi HK. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum 2008; 59(1): 109-116. https://doi.org/10.1002/art.23245
[35] Bae J, Chun B-Y, Park PS, Choi BY, et al. Higher consumption of sugar-sweetened soft drinks increases the risk of hyperuricemia in Korean population: The Korean Multi-Rural Communities Cohort Study. Seminars in Arthritis and Rheumatism 2014; 43(5): 654-61. https://doi.org/10.1016/j.semarthrit.2013.10.008
[36] Choi HK, Liu S, Curhan G. Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey. Arthritis Rheum 2005; 52(1): 283-289. https://doi.org/10.1002/art.20761
[37] Ho W-T. Analysis of purines and pyrimidinescontents of foods commonly consumed in Taiwan. J Chinese Nutr Soc 1986; 11: 41-62.
