HDL-C and Plaque Calcification are Associated with Microcirculatory Damage after Percutaneous Coronary Intervention
DOI:
https://doi.org/10.12970/2311-052X.2015.03.01.3Keywords:
Transposition of Great Arteries, arterial switch, follow-up, Magnetic Resonance Imaging, Pediatric, ulti-Detector Computer Tomography, Echocardiography.Abstract
Aims: Microvascular disturbance followed by percutaneous coronary intervention (PCI) was sometimes occurred. There were no report of the quantitative evaluation about microvascular disturbance after PCI. The aim of this study was to quantitate microcirculatory injury caused by elective PCI using index of microcirculatory resistance (IMR), and to clarify preprocedural predictors of microvascular damage.
Methods: Fifty patients with stable angina and planned PCI for single vessel disease were enrolled in this study. IMR was measured after PCI. Plaque components were analyzed by integrated backscatter intravascular ultrasound.
Results: Post-PCI IMR tended to correlate with high-density lipoprotein cholesterol levels (r = –0.298, p = 0.078) and plaque calcification (r = -0.22, p = 0.058) in the univariate analysis. Multivariate logistic analysis adjusted for these covariates revealed that the high-density lipoprotein cholesterol levels and plaque calcification were inversely associated with higher post-PCI IMR (odds ratio = 0.919, p = 0.049; and odds ratio = 0.546, p = 0.049, respectively).
Conclusion: Low levels of high-density lipoprotein cholesterol and plaque calcification independently predict higher post-PCI IMR. Based on these results, Serum lipid and plaque calcification profiles might be important for predicting and preventing periprocedural myocardial damage during elective PCI.
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