Insulin Resistance: Is it Prevalent in Egyptian Patients with Rheumatoid Arthritis?
DOI:
https://doi.org/10.12970/2310-9874.2015.03.01.5Keywords:
Rheumatoid arthritis, Insulin resistance, carotid atherosclerosisAbstract
Aim: to determine the prevalence of insulin resistance in a group of RA patients and to clarify the association between IR and the various disease parameters and the subclinical vascular pathology in those patients.
Subjects and Methods: The present study included 40 patients with RA in addition to 20 healthy age and sex matched controls. The study participants were subjected to careful history taking, thorough clinical examination and laboratory investigations including CRP, RF, ESR and insulin resistance. VAS and Disease activity score were calculated for all patients. Ultrasound assessment of carotid arteries was also performed.
Results: The study included 40 RA patients. The patients comprised 31 females (77.5 %) and 9 males (22.5 %) with a mean age of 42.7 ± 8.3 years and BMI of 28.6 ± 3.2 Kg/m2. Patients had significantly higher CIMT when compared with controls. Also, it was found that patients had significantly higher HOMA-IR when compared with control. HOMA-IR was significantly correlated with BMI and CIMT.
Conclusions: Insulin resistance is prevalent in RA patients and significantly contributes to the development of subclinical atherosclerosis in those patients.
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