Outcome of 69 Pregnancies within a Multinational Population with Systemic Lupus Erythematosus in Qatar
DOI:
https://doi.org/10.12970/2310-9874.2015.03.03.1Keywords:
Systemic lupus erythematosus, pregnancy, outcome, Qatar, Lupus nephritis.Abstract
The aim of this study is to determine the frequencies of abnormal pregnancy outcomes in a cohort of patients with systemic lupus erythematosus (SLE). Data of 69 pregnancies of 37 SLE patients were analyzed retrospectively. Lupus activity was assessed based on SLE Disease Activity Index (SLEDAI) criteria. Compared with pregnancies without Lupus nephritis (LN), pregnancies with LN were associated with a higher risk of still birth (p=0.092), higher rate of eclampsia (p=0.103), intrauterine growth restriction (IUGR) (p=0.556), and pregnancy induced hypertension (PIH) (p=0.412). PIH (17.4% vs 11.1%), IUGR (34.7% vs 11.8%), preterm delivery (26.1 % vs 11.8%), still birth (13% Vs 5.6%) and eclampsia (13% Vs 0%), all were observed to be higher in active lupus patients compared to those in remission. However, these differences were not statistically significant (p>0.05). Absence of LN, proteinuria and low complement component 3 (C3) were potential (p<0.15) predictors for live births. Anti-Ro antibodies, high anti-double stranded DNA antibody (anti-dsDNA), and low C3 were strongly associated with pre-term live births and Anti-Ro antibodies was significantly associated with IUGR. In conclusion SLE in pregnancies in a multinational population in Qatar was associated with higher adverse pregnancy outcomes. Disease activity during pregnancy, proteinuria, LN and eclampsia/preeclampsia were all negatively associated with pregnancy outcome such as IUGR, still births and preterm delivery. Laboratory parameters such as presence of Anti Ro/La antibody and low level of C3 were also associated with adverse pregnancy outcome.
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