Regulation of Collagen-Rich Matrix Remodeling in Wound Healing, Inflammation and Cancer
DOI:
https://doi.org/10.12970/2310-9874.2017.05.07Abstract
CD44 plays multiple roles in the context of inflammation and cancer including leukocyte recruitment, activation, and intratumoral migration [1,2]. CD44 also plays a role in the uptake of its principal ligand, hyaluronic acid (HA), and accumulation of soluble factors involved in stromal cell activation [1,2]. The role of CD44 in matrix remodeling is less well understood. Wound healing, inflammation and the microenvironment of solid tumors are all characterized by the accumulation and remodeling of HA and collagen-rich extracellular matrices. We have found that genetic deletion of CD44 results in increased fibrillar collagen accumulation in each of these conditions and that this phenotype is recapitulated in isolated fibroblast-derived matrices generated by CD44-deficient fibroblasts compared to wild-type fibroblasts in vitro. The mechanisms underlying CD44-mediated matrix remodeling and the consequences of altered matrix remodeling in each of these conditions in CD44-deficient mice compared to wild-type mice were discussed.
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