Oropharyngeal Swallowing Disorders in Parkinson’s Disease: Revisited
DOI:
https://doi.org/10.12970/2311-1917.2013.01.02.5Keywords:
Parkinson’s disease, oropharyngeal dysphagia, nutrition, neurophysiology.Abstract
Swallowing impairments in Parkinson’s Disease (PD) affect patients’ nutritional status, the oral administration of medication, and of course quality-of-life, even in the earlier stages of the disease. Here, we provide a synopsis of the current state of neurological diagnosis and the clinical value of the assessment for nutritional status and swallowing impairments in patients with PD. The recent position statement by European Society for Swallowing Disorders (ESSD) on the clinical assessment of dysphagic PD patients is also reviewed and discussed. Here, we also attempt to summarize and explain the recent findings from neurophysiological studies attempting to underpin the underlying mechanisms of the disease, preceding a short review of the therapeutic approaches. With this review, we aim to increase awareness for the deliberating consequences of swallowing impairments and provide a range of unanswered questions on different levels (physiological, neurophysiological, assessment and therapeutic procedures). Further investigations and collaborative large-scale research studies together with neurophysiological studies seem to be warranted in order to shape more effective clinical practice in the future.
References
Lo R and Tanner C, Epidemiology. In Pahwa R. and Lyons K (eds) Handbook of Parkinson’s Disease 5TH Edition, 2013, page 25.
Twelves D, Perkins KS, Counsell C. Systematic review of incidence studies of Parkinson's disease. MovDisord 2003; 18: 19-31. http://dx.doi.org/10.1002/mds.10305
Singleton AB, Farrer MJ, Bonifati V. The genetics of Parkinson's disease: progress and therapeutic implications. Mov Disord 2013; 28: 14-23. http://dx.doi.org/10.1002/mds.25249
Schrag A, Schott JM. Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism. Lancet Neurol 2006; 5: 355-63. http://dx.doi.org/10.1016/S1474-4422(06)70411-2
Moretto A, Colosio C. The role of pesticide exposure in the genesis of Parkinson's disease: epidemiological studies and experimental data. Toxicology 2013; 307: 24-34. http://dx.doi.org/10.1016/j.tox.2012.11.021
Kahle PJ. Alpha-Synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol 2008; 115: 87-95. http://dx.doi.org/10.1007/s00401-007-0302-x
Del Tredici K, Braak H.Lewy pathology and neurodegeneration in premotor Parkinson's disease. Mov Disord 2012; 27: 597-607. http://dx.doi.org/10.1002/mds.24921
Galvin JE, Lee VM, Trojanowski JQ. Synucleinopathies: clinical and pathological implications. Arch Neurol 2001; 58: 186-90. http://dx.doi.org/10.1001/archneur.58.2.186
Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res 2004; 318: 121-34. http://dx.doi.org/10.1007/s00441-004-0956-9
Del Tredici K, Rüb U, De Vos RA, Bohl JR, Braak H. Where does parkinson disease pathology begin in the brain? J Neuropathol Exp Neurol 2002; 61: 413-26.
Braak H, Rüb U, Gai WP, Del Tredici K. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 2003; 110: 517-36. http://dx.doi.org/10.1007/s00702-002-0808-2
Marek K, Innis R, van Dyck C, et al. Beta-CIT SPECT imaging assessment of the rate of Parkinson's disease progression.Neurology 2001; 57: 2089-94. http://dx.doi.org/10.1212/WNL.57.11.2089
Tissingh G, Booij J, Bergmans P, et al. Iodine-123-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iod ophenyl) tropane SPECT in healthy controls and early-stage, drug-naive Parkinson's disease. J Nucl Med 1998; 39: 1143-8.
Chaudhuri KR, Odin P, Antonini A, Martinez-Martin P. Parkinson's disease: the non-motor issues. Parkinsonism Relat Disord 2011; 17: 717-23. http://dx.doi.org/10.1016/j.parkreldis.2011.02.018
Park A, Stacy M. Non-motor symptoms in Parkinson's disease. J Neurol 2009; 256 (Suppl 3): 293-8. http://dx.doi.org/10.1007/s00415-009-5240-1
Wolters EC, Bosboom JLW. Parkinson's disease. In VU University Press (Ed.), Parkinsonism and Related Disorders 2007 (pp. 143-158). Amsterdam, the Netherlands: VU University Press.
Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical-diagnosis of idiopathic parkinsons-disease - a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181-4. http://dx.doi.org/10.1136/jnnp.55.3.181
Jellinger K. New developments in the pathology of Parkinson's disease. In: Streifler MB, Korczyn AD, Melamed E, Youdim MBH, eds. Advances in neurology Vol 53. Parkinson's disease. Anatomy, pathology, and therapy. NewYork: Raven Press, 1990:1-16.
Savica R, Grossardt BR, Bower JH, Ahlskog JE, Rocca WA. Incidence and pathology of synucleinopathies and tauopathies related to parkinsonism. JAMA Neurol 2013; 70: 859-66. http://dx.doi.org/10.1001/jamaneurol.2013.114
Hoehn M, Yahr M. Parkinsonism: onset, progression and mortality. Neurology 1967; 17: 427-42. http://dx.doi.org/10.1212/WNL.17.5.427
Lang AE, Eberly S, Goetz CG, et al. on behalf of the LABS-PD investigators. Movement disorder society unified Parkinson disease rating scale experiences in daily living: Longitudinal changes and correlation with other assessments. Mov Disord 2013; 28: 1980-6. http://dx.doi.org/10.1002/mds.25671
Michou E, Hamdy S. Dysphagia in Parkinson's disease: a therapeutic challenge? Expert Rev Neurother 2010; 10: 875-8. http://dx.doi.org/10.1586/ern.10.60
Baijens L, Speyer R, Lima Passos VL, Pilz W, Roodenburg N, Clavé P. Swallowing in Parkinson patients vs. healthy controls: Reliability of measurements in videofluoroscopy. Gastroenterol Res Pract Epub 2011; 2011:380682.
Ciucci MR, Grant LM, Rajamanickam ES, et al. Early identification and treatment of communication and swallowing deficits in Parkinsondisease. Semin Speech Lang 2013; 34: 185-2. http://dx.doi.org/10.1055/s-0033-1358367
Kalf JG, de Swart BJM, Bloem BR, Munneke M. Prevalence of oropharyngeal dysphagia in Parkinson's disease: a meta-analysis. Parkinsonism Related Disord 2012; 18: 311-5. http://dx.doi.org/10.1016/j.parkreldis.2011.11.006
Ertekin C, Tarlaci S, Aydogdu I, et al. Electrophysiological evaluation of pharyngeal phase of swallowing in patients with Parkinson’s disease. Mov Disord 2002; 17: 942-9. http://dx.doi.org/10.1002/mds.10240
Nagaya M, Teruhiko K, Yamada T, Igata A. Video fluorographic study of swallowing in Parkinson’s disease. Dysphagia 1998; 13: 95-100. http://dx.doi.org/10.1007/PL00009562
Wintzen AR, Badrising UA, Roos RA, Vielvoye J, Liauw L. Influence of bolus volume on hyoid movements in normal individuals and patients with Parkinson's disease. Can J Neurol Sci 1994; 21: 57-9.
Ali GN, Wallace KL, Schwartz R, Decarle DJ, Zagami AS, Cook IJ. Mechanisms of oral-pharyngeal dysphagia in patients with Parkinson’s disease. Gastroenterology 1996; 110: 383-92. http://dx.doi.org/10.1053/gast.1996.v110.pm8566584
Bushmann M, Dobmeyer SM, Leeker L, Perlmutter JS. Swallowing abnormalities and their response to treatment in Parkinson's disease. Neurology 1989; 39:1309-14. http://dx.doi.org/10.1212/WNL.39.10.1309
Rofes L, Arreola V, Almirall J, et al. Diagnosis and management of oropharyngeal Dysphagia and its nutritional and respiratory complications in the elderly. Gastroenterol Res Pract Article ID 818979, 13 pages.
Sheard JM, Ash S, Silburn PA, Kerr GK. Prevalence of malnutrition in Parkinson's disease: a systematic review. Nutr Rev 2011; 69: 520-32. http://dx.doi.org/10.1111/j.1753-4887.2011.00413.x
European Society for Swallowing Disorders Position Statements and Meeting Abstracts Uniting Europe Against Dysphagia Barcelona, Spain, October 25-27, 2012 Abstracts (2013). Dysphagia 28; 288-330.
860th meeting of the Ministers' Deputies (3 A.D.). Resolution ResAP (2003) on food and nutritional care in hospitals. Council of Europe, Committee of Ministers [On-line]. Available: https://wcd.coe.int/wcd/ViewDoc.jsp?Ref=ResAP (2003)3&Language=lanEnglish&Site=CM&BackColorInternet=C3C3C3&BackColorIntranet=EDB021&BackColorLogged=F5D383
Kaiser MJ, Bauer JM, Ramsch C, et al. Validation of the Mini Nutritional Assessment Short-Form (MNA®-SF): A practical tool for identification of nutritional status. J Nutr Health Aging 2009; 13: 782-8. http://dx.doi.org/10.1007/s12603-009-0214-7
Fernandez HH, Lapane KL. Predictors of mortality among nursing home residents with a diagnosis of Parkinson's disease. Med Sci Monit 2002; 8: CR241-CR246.
Almirall J, Cabré M, Clavé P. Complications of oropharyngeal dysphagia: aspiration pneumonia. Nestle Nutr Inst Workshop Ser 2012; 72: 67-76. http://dx.doi.org/10.1159/000339989
Ortega O, Parra C, Zarcero S, Nart J, Sakwinska O, Clavé P. Oral health in older patients with oropharyngeal dysphagia. Age Ageing 2014; 43: 132-7. http://dx.doi.org/10.1093/ageing/aft164
Williams-Gray CH, Mason SL, Evans JR, et al. The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort. J Neurol Neurosurg Psychiatry 2013; 84: 1258-64. http://dx.doi.org/10.1136/jnnp-2013-305277
Leopold NA, Kagel MC. Prepharyngeal dysphagia in Parkinson's disease. Dysphagia 1996; Winter; 11:14-22. http://dx.doi.org/10.1007/BF00385794
Edwards LL, Pfeiffer RF, Quigley EM, Hofman R, Balluff M. Gastrointestinal symptoms in Parkinson's disease. Mov Disord 1991; 6: 151-6. http://dx.doi.org/10.1002/mds.870060211
Bagheri H, Damase-Michel C, Lapeyre-Mestre M, et al. A study of salivary secretion in Parkinson's disease. Clin Neuropharmacol 1999; 22: 213-5.
Mu L, Sobotka S, Chen J, et al.; Arizona Parkinson’s Disease Consortium. Parkinson disease affects peripheral sensory nerves in the pharynx. J Neuropathol Exp Neurol 2013; 72: 614-23. http://dx.doi.org/10.1097/NEN.0b013e3182965886
Byrne KG, Pfeiffer R, Quigley EM. Gastrointestinal dysfunction in Parkinson's disease. A report of clinical experience at a single center. J Clin Gastroenterol 1994; 19: 11-6. http://dx.doi.org/10.1097/00004836-199407000-00004
Sung HY, Kim JS, Lee KS, et al. The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease. Mov Disord 2010; 25: 2361-8. http://dx.doi.org/10.1002/mds.23290
Cersosimo MG, Benarroch EE. Pathological correlates of gastrointestinal dysfunction in Parkinson's disease. Neurobiol Dis 2012; 46: 559-64. http://dx.doi.org/10.1016/j.nbd.2011.10.014
Tohara H, Nakane A, Murata S, et al. Inter- and intra-rater reliability in fiberoptic endoscopic evaluation of swallowing. J Oral Rehabil 2010; 37: 884-91. http://dx.doi.org/10.1111/j.1365-2842.2010.02116.x
Langmore SE, Aviv JE. Endoscopic evaluation and treatment of swallowing disorders. New York: Thieme; 2001.
Baijens LW, Speyer R, Passos VL, et al. Surface electrical stimulation in dysphagicparkinson patients: A randomized clinical trial. Laryngoscope 2013; 123: E38-44. http://dx.doi.org/10.1002/lary.24119
Manor Y, Mootanah R, Freud D, Giladi N, Cohen JT. Video-assisted swallowing therapy for patients with Parkinson's disease. Parkinsonism Relat Disord 2013; 19: 207-11. http://dx.doi.org/10.1016/j.parkreldis.2012.10.004
Wajsbort J. The “off-on” phenomenon during treatment of Parkinson’s disease with levodopa. J Neurol 1977; 15: 59-66. http://dx.doi.org/10.1007/BF00312550
Jankovic J, Tolosa E. Parkinson’s disease & movement disorders, fifth edition. Philadelphia: Lippincott Williams & Wilkins, Wolters Kluwer Business; 2007
Clave P, Arreola V, Romea M, Medina L, Palomera E, Serra-Prat M. Accuracy of the volume-viscosity swallow test for clinical screening of oropharyngeal dysphagia and aspiration. Clin Nutr 2008; 27: 806-15. http://dx.doi.org/10.1016/j.clnu.2008.06.011
Leow LP, Beckert L, Anderson T, Huckabee ML. Changes in chemosensitivity and mechanosensitivity in aging and Parkinson's disease. Dysphagia 2012; 27: 106-14. http://dx.doi.org/10.1007/s00455-011-9347-z
Clave P, de KM, Arreola V, et al. The effect of bolus viscosity on swallowing function in neurogenic dysphagia. Aliment Pharmacol Ther 2006; 24: 1385-94. http://dx.doi.org/10.1111/j.1365-2036.2006.03118.x
Bird MR, Woodward MC, Gibson EM, Phyland DJ, Fonda D. Asymptomatic swallowing disorders in elderly patients with Parkinsons-disease - a description of findings on clinical examination and video fluoroscopy in 16 patients. Age Ageing 1994; 23: 251-4. http://dx.doi.org/10.1093/ageing/23.3.251
Michou E, Hamdy S. Cortical input in control of swallowing. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 166-71. http://dx.doi.org/10.1097/MOO.0b013e32832b255e
Martin RE, Sessle BJ. The role of the cerebral cortex in swallowing. Dysphagia 1993; 8: 195-202. http://dx.doi.org/10.1007/BF01354538
Jean A. Control of the central swallowing program by inputs from the peripheral receptors. A review. J Auton Nerv Syst 1984; 10: 225-33. http://dx.doi.org/10.1016/0165-1838(84)90017-1
Barrett RT, Bao X, Miselis RR, Altschuler SM. Brain stem localization of rodent esophageal premotor neurons revealed by transneuronal passage of pseudorabies virus. Gastroenterology 1994; 107: 728-37.
Doty RW, Richmond WH, Storey AT. Effect of medullary lesions on coordination of deglutition. Exp Neurol 1967; 17: 91-106. http://dx.doi.org/10.1016/0014-4886(67)90125-2
Nambu A. A new dynamic model of the cortico-basal ganglia loop. Prog Brain Res 2004; 143: 461-6. http://dx.doi.org/10.1016/S0079-6123(03)43043-4
Bekiesinska-Figatowska M, Mierzewska H, Jurkiewicz E. Basal ganglia lesions in children and adults. Eur J Radiol 2013; 82: 837-49. http://dx.doi.org/10.1016/j.ejrad.2012.12.006
Rossi B, Siciliano G, Carboncini MC, et al. Muscle modifications in Parkinson’s disease: myoelectric manifestations. Electroencephalogr Clin Neurophysiol 1996; 101: 211-8. http://dx.doi.org/10.1016/0924-980X(96)94672-X
Mu L, Sobotka S, Chen J, et al. Altered pharyngeal muscles in Parkinson disease. J Neuropathol Exp Neurol 2012; 71: 520-30. http://dx.doi.org/10.1097/NEN.0b013e318258381b
Bloch A, Probst A, Bissig H, Adams H, Tolnay M. Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 2006; 32: 284-95. http://dx.doi.org/10.1111/j.1365-2990.2006.00727.x
Del Tredici K, Braak H. A not entirely benign procedure: progression of Parkinson's disease. Acta Neuropathol 2008; 115: 379-84. http://dx.doi.org/10.1007/s00401-008-0355-5
Hawkes CH, Del Tredici K, Braak H. Parkinson's disease: a dual-hit hypothesis. Neuropathol Appl Neurobiol 2007; 33: 599-614. http://dx.doi.org/10.1111/j.1365-2990.2007.00874.x
Jellinger KA. Lewy body-related alpha-synucleinopathy in the aged human brain. J Neural Transm 2004; 111: 1219-35. http://dx.doi.org/10.1007/s00702-004-0138-7
Li W, Hoffman PN, Stirling W, Price DL, Lee MK. Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations. J Neurochem 2004; 88: 401-10. http://dx.doi.org/10.1046/j.1471-4159.2003.02166.x
Li W, Lesuisse C, Xu Y, Troncoso JC, Price DL, Lee MK. Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. J Neurosci 2004; 24: 7400-9. http://dx.doi.org/10.1523/JNEUROSCI.1370-04.2004
Kessler JP, Jean A. Inhibition of the swallowing reflex by local application of serotonergic agents into the nucleus of the solitary tract. Eur J Pharmacol 1985; 118: 77-85. http://dx.doi.org/10.1016/0014-2999(85)90665-X
Weerasuriya A, Bieger D, Hockman CH. Basal forebrain facilitation of reflex swallowing in the cat. Brain Res 1979; 174: 119-33. http://dx.doi.org/10.1016/0006-8993(79)90808-4
Jellinger K. The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease. J Neurol Neurosurg Psychiatry 1988; 51: 540-3. http://dx.doi.org/10.1136/jnnp.51.4.540
Glinka Y, Gassen M, Youdim MB. Mechanism of 6-hydroxydopamine neurotoxicity. J Neural Transm Suppl 1997; 50: 55-66. http://dx.doi.org/10.1007/978-3-7091-6842-4_7
Fleming SM, Schallert T, Ciucci MR. Cranial and related sensorimotor impairments in rodent models of Parkinson's disease. Behav Brain Res 2012; 231: 317-22. http://dx.doi.org/10.1016/j.bbr.2012.02.034
Russell JA, Ciucci MR, Hammer MJ, Connor NP. Video fluorographic assessment of deglutitive behaviors in a rat model of aging and Parkinson disease. Dysphagia 2013; 28: 95-104. http://dx.doi.org/10.1007/s00455-012-9417-x
Connor NP, Russell JA, Wang H, Jackson MA, Mann L, Kluender K Effect of tongue exercise on protrusive force and muscle fiber area in aging rats. J Speech Lang Hear Res 2009; 52: 732-44. http://dx.doi.org/10.1044/1092-4388(2008/08-0105)
Behan M, Moeser AE, Thomas CF, Russell JA, Wang H, Leverson GE, Connor NP. The effect of tongue exercise on serotonergic input to the hypoglossal nucleus in young and old rats. J Speech Lang Hear Res 2012; 55: 919-29. http://dx.doi.org/10.1044/1092-4388(2011/11-0091)
Guggenmos DJ, Barbay S, Bethel-Brown C, Nudo RJ, Stanford JA. Effects of tongue force training on orolingual motor cortical representation. Behav Brain Res 2009; 201: 229-32. http://dx.doi.org/10.1016/j.bbr.2009.02.020
Ciucci MR, Russell JA, Schaser AJ, Doll EJ, Vinney LM, Connor NP. Tongue force and timing deficits in a rat model of Parkinson disease. Behav Brain Res 2011; 222: 315-20. http://dx.doi.org/10.1016/j.bbr.2011.03.057
Ciucci MR, Schaser AJ, Russell JA. Exercise-induced rescue of tongue function without striatal dopamine sparing in a rat neurotoxin model of Parkinson disease. Behav Brain Res 2013; 252: 239-45. http://dx.doi.org/10.1016/j.bbr.2013.06.004
Plowman EK, Maling N, Thomas NJ, Fowler SC, Kleim JA. Targeted motor rehabilitation dissociates corticobulbar vs corticospinal dysfunction in an animal model of Parkinson's disease. Neurorehabil Neural Repair 2014; 28: 85-95. http://dx.doi.org/10.1177/1545968313498648
Nóbrega AC, Pinho P, Deiró M, Argolo N. Levodopa treatment in Parkinson's disease: How does it affect dysphagia management? Parkinsonism Relat Disord 2013 Sep 20. pii: S1353-8020(13)00343-X. [Epub ahead of print] http://dx.doi.org/10.1016/j.parkreldis.2013.09.013
Hunter PC, Crameri J, Austin S, Woodward MC, Hughes J. Response of parkinsonian swallowing dysfunction to dopaminergic stimulation. J Neurol Neurosurg Psychiatry 1997; 63: 579-83. http://dx.doi.org/10.1136/jnnp.63.5.579
Melo A, Monteiro L.Swallowing improvement after levodopa treatment in idiopathic Parkinson's disease: Lack of evidence. Parkinsonism Relat Disord 2013; 19: 279-81. http://dx.doi.org/10.1016/j.parkreldis.2012.11.017
Menezes C, Melo A. Does levodopa improve swallowing dysfunction in Parkinson's disease patients? J Clin Pharm Ther 2009; 34: 673-6. http://dx.doi.org/10.1111/j.1365-2710.2009.01031.x
Menke RA, Jbabdi S, Miller KL, Matthews PM, Zarei M. Connectivity-based segmentation of the substantianigra in human and its implications in Parkinson's disease. Neuroimage 2010; 52: 1175-80. http://dx.doi.org/10.1016/j.neuroimage.2010.05.086
Sharman M, Valabregue R, Perlbarg V, et al. Parkinson's disease patients show reduced cortical-subcortical sensorimotor connectivity. Mov Disord 2013; 28: 447-54. http://dx.doi.org/10.1002/mds.25255
Kikuchi A, Baba T, Hasegawa T, et al. Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study. BMJ Open 2013; 3: e002249. http://dx.doi.org/10.1136/bmjopen-2012-002249
Suntrup S, Teismann I, Bejer J, et al. Evidence for adaptive cortical changes in swallowing in Parkinson's disease. Brain 2013; 136: 726-38. http://dx.doi.org/10.1093/brain/awt004
Troche MS, Brandimore AE, Foote KD, Okun MS. Swallowing and deep brain stimulation in Parkinson’s disease: a systematic review. Parkinsonism Relat Disord 2013; 19: 783-8. http://dx.doi.org/10.1016/j.parkreldis.2013.05.001
Baijens LWJ, Speyer R. Effects of therapy for dysphagia in Parkinson’s disease: systematic review. Dysphagia 2009; 24: 91-102. http://dx.doi.org/10.1007/s00455-008-9180-1
Calne DB, Shaw DG, Spiers AS, Stern GM. Swallowing in Parkinsonism. Br J Radiol 1970; 43: 456-7. http://dx.doi.org/10.1259/0007-1285-43-511-456
Fuh JL, Lee RC, Wang SJ, Lin CH, Wang PN, Chiang JH, Liu HC. Swallowing difficulty in Parkinson’s disease. Clin Neurol Neurosurg 1997; 99: 106-12.
Sutton JP.Dysphagia in Parkinson's disease is responsive to levodopa. Parkinsonism Relat Disord 2013; 19: 282-4. http://dx.doi.org/10.1016/j.parkreldis.2012.11.007
Tawadros PB, Cordato D, Cathers I, Burne JA. An electromyographic study of parkinsonian swallowing and its response to levodopa. Mov Disord 2012; 27: 1811-5. http://dx.doi.org/10.1002/mds.25262
Lim A, Leow L, Huckabee ML, Frampton C, Anderson T. A pilot study of respiration and swallowing integration in Parkinson’s disease: ‘‘on’’ and ‘‘off’’ levodopa. Dysphagia 2008; 23: 76-81. http://dx.doi.org/10.1007/s00455-007-9100-9
Born LJ, Harned RH, Rikkers LF, Pfeiffer RF, Quigley EM. Cricopharyngeal dysfunction in Parkinson‘s disease: role in dysphagia and response to myotomy. Mov Disord 1996; 11: 53-8. http://dx.doi.org/10.1002/mds.870110110
Logemann JA, Gensler G, Robbins JA, et al. A randomized study of three interventions for aspiration of thin liquids in patients with dementia or Parkinson’s disease. J Speech Lang Hear Res 2008; 51: 173-83.
Pinnington LL, Muhiddin KA, Ellis RE, Playford ED. Non-invasive assessment of swallowing and respiration in Parkinson’s disease. J Neurol 2000; 247: 773-7. http://dx.doi.org/10.1007/s004150070091
El Sharkawi A, Ramig L, Logemann JA, et al. Swallowing and voice effects of Lee Silverman Voice Treatment (LSVT): a pilot study. J Neurol Neurosurg Psychiatry 2002; 72: 31-6. http://dx.doi.org/10.1136/jnnp.72.1.31
Troche MS, Okun MS, Rosenbek JC, et al. Aspiration and swallowing in Parkinson disease and rehabilitation with EMST: a randomized trial. Neurology 2010; 75: 1912-9. http://dx.doi.org/10.1212/WNL.0b013e3181fef115
Manor Y, Mootanah R, Freud D, Giladi N, Cohen JT. Video-assisted swallowing therapy for patients with Parkinson's disease. Parkinsonism Relat Disord 2013; 19: 207-11. http://dx.doi.org/10.1016/j.parkreldis.2012.10.004
Regan J, Walshe M, Tobin WO. Immediate Effects of Thermal–Tactile Stimulation on Timing of Swallow in Idiopathic Parkinson’s Disease. Dysphagia 2010; 25: 207-15. http://dx.doi.org/10.1007/s00455-009-9244-x
Baijens LWJ, Speyer R, Passos VL, Pilz W, Roodenburg N, Clave P. The effect of surface electrical stimulation on swallowing in dysphagic Parkinson patients. Dysphagia 2012; 27: 528-37. http://dx.doi.org/10.1007/s00455-011-9387-4
Heijnen BJ, R Speyer, Baijens LWJ, Bogaardt HCA. Neuromuscular electrical stimulation vs. traditional therapy in patients with Parkinson’s disease and oropharyngeal dysphagia: Effects on quality of life. Dysphagia 2012; 27: 336-45. http://dx.doi.org/10.1007/s00455-011-9371-z
Silbergleit AK, LeWitt P, Junn F, et al. Comparison of dysphagia before and after deep brain stimulation in Parkinson's disease. Mov Disord 2012; 27: 1763-8. http://dx.doi.org/10.1002/mds.25259
Wolz M, Hauschild J, Fauser M, Klingelhofer L, Reichmann H, Storch A. Immediate effects of deep brain stimulation of the subthalamic nucleus on nonmotor symptoms in Parkinson’s disease. Parkinsonism Relat Disord 2012:18; 994-7. http://dx.doi.org/10.1016/j.parkreldis.2012.05.011
Ciucci MR, Barkmeier-Kraemer JM, Sherman SJ. Subthalamic nucleus deep brain stimulation improves deglutition in Parkinson’s disease. Mov Disord 2008; 15: 676-83. http://dx.doi.org/10.1002/mds.21891