https://synergypublishers.com/pms/index.php/ijcpmh <p><strong>Aim of Scope</strong></p> <p><strong>International Journal of Clinical Psychiatry and Mental Health</strong> is a peer-reviewed medical journal, which strengthen the research and educational base of psychiatry. The journal provides an active platform for researchers, educators, and clinicians concerned with mental health, primary health care and related aspects of medical care from around the world. The Journal is dedicated to provide reliable, valid clinical and scientific information about mental health care and improve the quality of mental health disorders.</p> <p>The Journal welcomes empirical papers as well as occasional reviews and associated theoretical formulations regarding research related to clinical issues at all levels of analysis (from genes and molecules to contexts and cultures), using the full range of behavioral and biological methods, and incorporating both human and non-human animal models.</p> Synergy Publishers en-US International Journal of Clinical Psychiatry and Mental Health 2310-8231 https://synergypublishers.com/pms/index.php/ijcpmh/article/view/2306 <p>Down syndrome (DS) is the most frequent autosomal aneuploidy. It refers to a genetic condition due to the triplication of human chromosome 21 (Hsa21). Disruption of the phenotype is thought to be the result of gene-dosage imbalance. This phenotype is always characterized by neurodevelopmental anomalies. Additionally, persons with DS have higher risks of several medical challenges. These include congenital heart disease, susceptibility to viruses and immune defects, metabolic changes, and hematopoietic abnormalities. In recent years, experimental work has been conducted with the aim of correcting overexpressed genes on chromosome 21 or silencing the extra chromosome 21 to normalize genetic expression. The paper examines the clinical feasibility of these attempts and identifies several caveats. Improving neurogenesis, dendritic density and synaptic connectivity with pharmacological substances is more at hand with the current technical knowledge and legal provisos.</p> Jean Adolphe Rondal Copyright (c) 2024 2024-02-08 2024-02-08 12 1 7 10.12970/2310-8231.2024.12.01