Outline of an Action-Oriented Classification of Mental Disorders: A Hypothetical Model
DOI:
https://doi.org/10.12970/2310-8231.2014.02.02.5Keywords:
Mental disorders, synaptic imbalance, disordered intentionality, therapeutic feasibility, classification.Abstract
The outline of an action-oriented classification of mental disorders is mainly theoretically proposed. Based on the discussion and interpretation of the “Schichtenregel” (three-layer-rule) by the German psychiatrist Karl Jaspers, a synaptic model is elaborated for the pathophysiology of depression, mania and schizophrenia. According to a logic of balance, synapses may be balanced, underbalanced (depression), overbalanced (mania), or unbalanced (schizophrenia). From a psychological point of view, patients with a major depression are hyperintentional, patients with mania are hypointentional, and in the case of schizophrenia they are dysintentional. Decisive in the synaptic model proposed is the number of receptors for neurotransmitters expressed in the membranes of astrocytes. A normal or disturbed balance of behavior can be described as variables of the intentional programs and as values of the description of their feasibility. This enables a computer supported classification of an action-oriented diagnostic manual. The future realization of this procedure may improve psychiatric research and especially clinical practice.
References
Mitterauer B. Praeludia. Technik und Spielarten der zwischenmenschlichen Kommunikation: vorgespielt in unseren Gehirnen. Salzburg: Paracelsus 2013.
Witter H. Unterschiedliche Perspektiven in der allgemeinen und in der forensischen Psychiatrie. Berlin: Springer 1990. http://dx.doi.org/10.1007/978-3-642-75162-2
Addario-Berry L, Reeve P. Mental health: maybe human troubles don‘t fit into set categories. Nature 2008; 14: 454-824.
McCulloch WS. Embodiments of mind. Cambridge, MA: The MIT Press 1965.
Jaspers K. Allgemeine Psychopathologie. Berlin: Springer 1973.
Mitterauer BJ. Synaptic imbalances in endogenous psychoses. BioSystems 2010; 100: 113-21. http://dx.doi.org/10.1016/j.biosystems.2010.02.006
Mitterauer BJ. Narziss und Echo. Ein psychobiologisches Modell der Depression. Vienna: Springer 2009. http://dx.doi.org/10.1007/978-3-211-99140-4
Mitterauer B. Imbalances of glial-neuronal interaction in synapses: a possible mechanism of the pathophysiology of bipolar disorder. Neuroscientist 2004; 10: 199-206. http://dx.doi.org/10.1177/107385403262248
Mitterauer B. Pseudoomnipotence. A model of the manic syndrome. In: Kotlar BB, Ed. New developments in mania research. New York: Nova Science Publishers 2006; pp. 161-78.
Mitterauer B. Der Maniker. Der Praktische Arzt 1990; 44: 5-13.
Mitterauer B. Nonfunctional proteins in tripartite synapses: a pathophysiological model of schizophrenia. Neuroscientist 2005; 11: 192-8. http://dx.doi.org/10.1177/1073858404265745
Guenther G. Das Bewusstsein der Maschinen. Krefeld: Agis 1963.
Runes DD. Dictionary of philosophy. Ames, Littlefield: Adams and Co. 1959.
Krippendorff K. A dictionary of cybernetics. Pennsylvania: the Annenberg School of Communication 1986.
Gallo V, Chittajallu R. Receptors for synaptic transmitters on glial cell plasma membrane: role in glial cell proliferation and maturation. In: Volterra A, Magistretti PJ, Haydon PG. Eds. The Tripartite Synapse: Glia in Synaptic Transmission. Oxford: University Press 2002; pp. 35-46.
Haydon PG, Araque A. Astrocytes as modulators of synaptic transmission. In: Volterra A, Magistretti PJ, Haydon PG, Eds. The Tripartite Synapse: Glia in Synaptic Transmission. Oxford: University Press 2002; pp. 185-198.
Oliet SH, Piet R, Poulan DA. Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science 2001; 292: 923-6. http://dx.doi.org/10.1126/science.1059162
Spaete R, Jackman T. Non-splicing variants of gp. 350/220 US Patent 6458364 2002.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Washington: American Psychiatric Association 1998.
Post RM. Mood disorders: somatic treatment. In: Kaplan HJ, Sadock BJ, Eds. Comprehensive Textbook of Psychiatry. Baltimore: Williams and Wilkins 1995; pp. 1152-1178.
Bunny WE, Davis JM. Norepinephrine in depressive reactions: a review. Arch gen psych 1965; 13: 335-45. http://dx.doi.org/10.1002/mds.10114
Schildkraut JJ. The cholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psych 1965; 120: 509-22.
Siever LJ, Davis KL. Overview: toward a dysregulation hypothesis of depression. Am J Psych 1985; 142: 1017-31.
Burn DJ. Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson’s disease. Mov Dis 2002; 17: 445-54.
Mellerup E, Kristensen F. Mania as a dysfunction of reentry: application of Edelman’s and Tononi’s hypothesis for consciousness to psychiatric disorder. MEHY 2004; 63: 464-6.
Edelman GM, Tononi C. A universe of consciousness. New York: Basic Books 2000.
Akiskal HS. Mood disorders. In: Kaplan HJ, Sadock BJ, Eds. Comprehensive Textbook of Psychiatry. Baltimore: Williams and Wilkins 1995; pp. 1123-52.
Meltzer H. Multiple neurotransmitters involved in antipsychotic drug action. In: Kapur S, Lecrubier Y, Eds. Dopamine in the pathophysiology and treatment of schizophrenia. London: Martin Dunitz 1998; pp. 177-205.
Carpenter WT, Buchanan RW. Schizophrenia: introduction and overview. In: Kaplan HJ, Sadock BJ, Eds. Comprehensive Textbook of Psychiatry. Baltimore: Williams and Wilkins 1995; pp. 889-902.
Shastry BS. Schizophrenia: a genetic perspective. Int J Mol Med 2002; 9: 207-12.
Kapur S, Lecrubier Y. Dopamine in the pathophysiology and treatment of schizophrenia. London: Martin Dunitz 2003.
Fisher S, Cleveland SE. Body image and personality. New York: Dover 1968.
Sims A. An overview of the psychopathology of perception: first rank symptoms as a localizing sign in schizophrenia. Psychopathology 1991; 24: 367-74. http://dx.doi.org/10.1159/000284740
Mitterauer B. The loss of self-boundaries: towards a neuromolecular theory of schizophrenia. BioSystems 2003; 72: 209-15. http://dx.doi.org/10.1016/S0303-2647(03)00144-8
Mitterauer B. An interdisciplinary approach towards a theory of consciousness. BioSystems 1998; 45: 99-121. http://dx.doi.org/10.1016/S0303-2647(97)00070-1
Mitterauer B, Kopp C. The self-composing brain: towards a glial-neuronal brain theory. Brain and Cognition 2003; 51: 357-67. http://dx.doi.org/10.1016/S0278-2626(03)00043-5
Antanitus DS. A theory of cortical neuron-astrocyte interaction. Neuroscientist 1998; 4: 154-9. http://dx.doi.org/10.1177/107385849800400310
Fellin T, Pascual O, Haydon PG. Astrocytes coordinate synaptic networks: balanced excitation and inhibition. Physiology 2006; 21: 208-15. http://dx.doi.org/10.1152/physiol.00161.2005
Mitterauer B. Clocked perception system. JIS 2001; 11: 269-97.
Rall W. Theoretical significance of dendrite trees for neuronal input-output relations. In: Segev I, Rinzel J, Shepherd GM, Eds. The theoretical foundation of dendrite function. Cambridge: MIT Press 1995; pp. 122-46.
Rothuber H, Mitterauer B. Comprehensive behavioral analysis of patients with a major depressive episode. Med Sci Monit 2011; 17: CR 259-64.
Iberall AS, McCulloch WS. The organizing principle of complex living systems. Transactions of the ASME 1969; 290-4.
Mitterauer B. Where and how could intentional programs be generated in the brain? A hypothetical model based on glial-neuronal interactions. BioSystems 2007; 88: 101-12. http://dx.doi.org/10.1016/j.biosystems.2006.04.003