Functional and Neuropsychological Abilities in Adults with Fetal Alcohol Spectrum Disorders

Authors

  • Ada W.S. Leung Department of Occupational Therapy, University of Alberta, T6G 2G4, Canada and Neuroscience and Mental Health Institute, University of Alberta, T6G 2E1, Canada
  • Sharon E. Brintnell Department of Occupational Therapy, University of Alberta, T6G 2G4, Canada and Occupational Performance Analysis Unit, Faculty of Rehabilitation Medicine, University of Alberta, T6G 2G4, Canada
  • Kimberly D. Long Department of Occupational Therapy, University of Alberta, T6G 2G4, Canada
  • Xianzhi Chen Department of Occupational Therapy, University of Alberta, T6G 2G4, Canada and School of Social Development and Public Policy, Fudan University, Shanghai, China
  • Monty Nelson Department of Educational Psychology, University of Alberta, T6G 2E1, Canada

DOI:

https://doi.org/10.12970/2310-8231.2016.04.01.3

Keywords:

Fetal alcohol spectrum disorder, neuropsychological assessment, functional assessment, cross-sectional study.

Abstract

Objective: This study investigated functional and neuropsychological abilities in adults with mild to moderate fetal alcohol spectrum disorder (FASD).

Method: Sixty-eight participants completed various neuropsychological tests such as the California Verbal Learning Test – 2nd edition (CVLT-2), Trail Making Test parts A and B (TMTA/TMTB), Stroop Color and Word Test (Stroop), Grooved Pegboard Test (GPT), Finger Tapping Test (FTT), and Independent Living Scales (ILS). Independent samples t-tests were used to compare performance between brain scores 2 and 3. Hierarchical logistic regression was used to identify predictors for brain scores.

Results: Adults with severe impairment (i.e., a brain score of 3) performed significantly worse than those with milder brain dysfunction (i.e., a brain score of 2) on TMTB, Stroop, CVLT-2, and ILS (money management, and managing home and transportation subscales). Test scores from the CVLT-2 (long-delay cued recall) and ILS (money management subscale) predicted brain scores.

Conclusions: Psychosocial ability remained low in all participants and should be assessed as a discrete factor for guiding interventions in adults. The results provided an important piece of reference in support of the inclusion of psycho-emotional elements in the new diagnostic guidelines for FASD.

References

Astley S. Diagnostic guidelines for fetal alcohol spectrum disorders: the 4-digit diagnostic code (3rd ed.). Seattle, WA: University of Washington Publication Services 2004.

Chudley AE, Conry J, Cook JL, Loock C, Rosales T, LeBlanc N. Public Health Agency of Canada's National Advisory Committee on Fetal Alcohol Spectrum Disorder. Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis. Canadian Medical Association Journal 2005; 172(5 Suppl): S1-S21. http://dx.doi.org/10.1503/cmaj.1040302

Kodituwakku PW. A neurodevelopmental framework for the development of interventions for children with fetal alcohol spectrum disorders. Alcohol 2010; 44(7-8): 717-728. http://dx.doi.org/10.1016/j.alcohol.2009.10.009

Clark E, Lutke J, Minnes P, Ouellette-Kuntz H. Secondary disabilities among adults with fetal alcohol spectrum disorder in British Columbia. Journal of Fetal Alcohol Syndrome International 2004; 2(13): 1-12. http://dx.doi.org/10.1111/j.1746-1561.2007.00178.x

Green JH. Fetal Alcohol Spectrum Disorders: Understanding the effects of prenatal alcohol exposure and supporting students. The Journal of School Health 2007; 77(3): 103-108.

Di Pietro NC, Illes J. Disparities in Canadian Indigenous health research on neurodevelopmental disorders. Journal of Developmental and Behavioral Pediatrics 2014; 35(1): 74-81. http://dx.doi.org/10.1097/DBP.0000000000000002

Salmon A, Clarren SK. Developing effective, culturally appropriate avenues to FASD diagnosis and prevention in northern Canada. International Journal of Circumpolar Health 2011; 70(4): 428-433. http://dx.doi.org/10.3402/ijch.v70i4.17844

Clarren SK, Lutke J, Sherbuck M. The Canadian guidelines and the interdisciplinary clinical capacity of Canada to diagnose fetal alcohol spectrum disorder. Journal of Population Therapeutics and Clinical Pharmacology 2011; 18(3): e494-499.

Lakeland Centre for FASD. 2014 Rajani FASD assessment & diagnostic clinic training services. Retrieved February 2, 2015; from: http://lcfasd.com/training/

Olson HC, Feldman JJ, Streissguth AP, Sampson PD, Bookstein FL. Neuropsychological deficits in adolescents with fetal alcohol syndrome: clinical findings. Alcoholism, Clinical and Experimental Research 1998; 22(9): 1998-2012. http://dx.doi.org/10.1097/00000374-199812000-00016

Rasmussen C, Horne K, Witol A. Neurobehavioral functioning in children with fetal alcohol spectrum disorder. Child Neuropsychology 2006; 12(6): 453-468. http://dx.doi.org/10.1080/09297040600646854

Schonfeld AM, Mattson SN, Lang A R, Delis DC, Riley EP. Verbal and nonverbal fluency in children with heavy prenatal alcohol exposure. Journal of Studies on Alcohol 2001; 62(2): 239-246. http://dx.doi.org/10.15288/jsa.2001.62.239

Schonfeld AM, Paley B, Frankel F, O'Connor MJ. Executive functioning predicts social skills following prenatal alcohol exposure. Child Neuropsychology 2006; 12(6): 439-452. http://dx.doi.org/10.1080/09297040600611338

Brintnell SE, Sawhney A, Palmer T, Morgovsky S, Nelson M, Heard N, Mckinon K. Report on corrections to community connections project. The government of Alberta: Tri ministries 2012.

Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test (2nd ed). San Antonio, TX: Psychological Corporation 2000.

Christidi F, Kararizou E, Triantafyllou N, Anagnostouli M, Zalonis I. Derived Trail Making Test indices: demographics and cognitive background variables across the adult life span. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition 2015; 22(6): 667-678. http://dx.doi.org/10.1080/13825585.2015.1027650

Oosterman JM, Vogels RL, van Harten B, Gouw AA, Poggesi A, Scheltens P, Kessels RPC, Scherder EJ. Assessing mental flexibility: neuroanatomical and neuropsychological correlates of the Trail Making Test in elderly people. The Clinical Neuropsychologist 2010; 24(2): 203-19. http://dx.doi.org/10.1080/13854040903482848

Stroop JR. Studies of interference in serial verbal reactions. Journal of Experimental Psychology 1935; 18: 643-662. http://dx.doi.org/10.1037/h0054651

Fouty HE, McWaters AR, Sanchez HC, Mills RA, Brandon BM, Weitzner DS. Effect of left-hand peg placement direction on the Grooved Pegboard Test. Applied Neuropsychology: Adult 2015; 22(5): 332-334. http://dx.doi.org/10.1080/23279095.2014.930039

Axelrod BN, Meyers JE, Davis JJ. Finger Tapping Test performance as a measure of performance validity. The Clinical Neuropsychologist 2014; 28(5): 876-888. http://dx.doi.org/10.1080/13854046.2014.907583

Loeb PA. ILS: Independent living scales manual. San Antonio, TX: The Psychological Corporation 1996.

Ahmed FS, Miller LS. Adequate proverb interpretation is associated with performance on the independent living scales. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition 2015; 22(3): 376-387. http://dx.doi.org/10.1080/13825585.2014.952613

Hintze J. NCSS and PASS. Number Cruncher Statistical Systems. Kaysville, Utah. www.NCSS.com.

Golden SD, McLeroy KR, Green LW, Earp JA, Lieberman LD. Upending the social ecological model to guide health promotion efforts toward policy and environmental change. Health Education & Behavior 2015; 42(1 Suppl): 8S-14S. http://dx.doi.org/10.1177/1090198115575098

Anderies JM. Understanding the dynamics of sustainable social-ecological systems: human behavior, institutions, and regulatory feedback networks. Bulletin of Mathematical Biology 2015; 77(2): 259-280. http://dx.doi.org/10.1007/s11538-014-0030-z

Lezak MD, Howieson DB, Loring DW. Neuropsychological Assessment (4th ed.). New York 2004; NY: Oxford University Press, Inc.

Donders J, Nienhuis JB. Utility of California Verbal Learning Test, Second Edition, recall discriminability indices in the evaluation of traumatic brain injury. Journal of the International Neuropsychological Society 2007; 13(2): 354-358. http://dx.doi.org/10.1017/S1355617707070439

Jia H, Moriarty DG, Kanarek N. County-level social environment determinants of health-related quality of life among US adults: a multilevel analysis. Journal of Community Health 2009; 34(5): 430-9. http://dx.doi.org/10.1007/s10900-009-9173-5

Dej E. What once was sick is now bad: the shift from victim to deviant identity for those diagnosed with fetal alcohol spectrum disorder. Canadian Journal of Sociology 2011; 361: 137-160.

World Health Organization. Health Impact Assessment 2015. Retrieved from: http://www.who.int/hia/evidence/doh/en/

Alberta Government (2014). Institute of Health Economics. Available from: http://www.ihe.ca

Heaton J. Reworking qualitative data. Thousand Oaks; CA: Sage Publications Inc 2004.

Kully-Martens K, Denys K, Treit S, Tamana S, Rasmussen C. A review of social skills deficits in individuals with fetal alcohol spectrum disorders and prenatal alcohol exposure: profiles, mechanisms, and interventions. Alcoholism, Clinical and Experimental Research 2012; 36(4): 568-76. http://dx.doi.org/10.1111/j.1530-0277.2011.01661.x

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Published

2016-03-06

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