Actinic Cheilitis Treated with Photodynamic Therapy: Case Report of an Innovative Successful Therapy
Authors
Francisca Reculé1, María Teresa Barroilhet2, Maximiliano Curi3, Marianne Kolbach 4 and Sergio González5 1Medical Physician, Internal Medicine Department, Hospital de Carabineros, Santiago, Chile; 2Medicine Student, Los Andes University, Santiago, Chile; 3Dermatology Resident, Pontificia Universidad Católica de Chile; 4Asistent Professor, Dermatology Department, Pontificia Universidad Católica de Chile; 55Asistent Professor, Histopathology Department, Pontificia Universidad Católica de Chile
Actinic cheilitis (AC) is a chronic inflammatory disease, considered the main precancerous lesion of the lip, due to it antecedents squamous cell carcinoma (SCC). AC pathogenesis is related to ultraviolet radiation (UVR) chronic exposure with persistent elastosis, but genetic predisposition also has been proved. Multiple therapies have been used with moderate success, being recently proposed photodynamic therapy (PDT). We want to report a case which although is not rare; it was treated with an innovative therapy (PDT). A 28-year-old male consulted for a 9-month evolution history characterized by recurrent lip dryness, ulcers and fissures. At the physical exam an erythematous plaque with hyperkeratotic edge of the lower lip was observed. Histological study revealed an AC with moderate dysplasia. Two sessions of PDT with methyl aminolevulinate (METVIX) and red light were performed, with excellent clinical and histological response. Control biopsy demonstrated non-dysplastic AC. We propose that PDT is a new and effective non-invasive available option for treatment of AC.
