Acquired Hyperpigmentation of the Tongue Associated with Hydroxyurea: Case Report of a Very Rare Location of a Rare Adverse Effect
Authors
Nigel P. Murray1,2 Maximiliano Echavarría3 Francisca Reculé4 Maximiliano Miranda 4 and Álvaro Ferres5 1Hematologist, Dept. of Medicine, Hospital de Carabineros de Chile, Simón Bolivar, Nuñoa, Santiago, Chile; 2Professor of Hematology and Internal Medicine, University Finis Terrae, Av. Pedro de Valdivia 1509, Providencia, Santiago, 7501015, Chile; 3Dental Student, Faculty of Odontology, University del Desarrollo, Av. Las Condes 12587, Las Condes, Santiago, 7590943, Chile; 4Dept. of Internal Medicine, Hospital de Carabineros de Chile, Simón Bolivar, Nuñoa, Santiago, 7770199, Chile; 5Facial-Maxillar Consultant Surgeon, Dept Facial-Maxiliar, Hospital de Carabineros de Chile, Simón Bolivar, Nuñoa, Santiago, Chile
Changes in pigmentation has been reported for differing chemotherapeutic agents, such as cyclophosphamide, anthracyclines as well as hydroxyurea. Generalized hyperpigmentation as well as melanonychia has been well reported for hydroxyurea, which is neither dose dependent or related to the duration of treatment. It has never been report a case of hyperpigmentation of the tongue associated with the use of hydroxyurea, although it has been reported with other chemotherapeutic agents. We report a case of hyperpigmentation of the tongue associated with the use of hydroxyurea, discuss the differential diagnosis and a review the literature.
