Risk of Venous Thromboembolism in Hospitalized Psoriasis Patients
Authors
Christopher G. Gibson1, Bhakti B. Chavan2, Ruby S. Gibson3, Francis Essien4, Melissa J. Newman1, Robert L. Zee1, Stephanie J. Ott5 and Irving L. Rosenberg5 1Department of Internal Medicine, Fairfield Medical Center, Lancaster, Ohio, USA; 2Ohio University Heritage College of Osteopathic Medicine, Dublin, OH, USA; 3Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA; 4Department of Internal Medicine, Keesler Air Force Base, Biloxi, MS, USA; 5Department of Rheumatology at the Fairfield Medical Center, Lancaster, OH, USA
Background: Psoriasis is associated with increased mortality but the underlying pathophysiology has yet to be copiously recognized. There are several models that demonstrate that psoriasis is not only a disease of the skin, but also has major systemic involvement of the internal organs. Psoriasis is a chronic inflammatory skin disease with a wide range of clinical manifestations. The purpose of this article is to evaluate a nationwide database to compare the incidence, prevalence, and inpatient burden of venous thromboembolism in patients with and without psoriasis. Methods and Results: A cross-sectional study to examine the risk of incidence of VTE among patients with PsO. A total of 31,268 patients (0.4%) were diagnosed with PsO in a sample size of 7,103,377 (99.6%). A greater proportion of patients with PsO experienced either a DVT or PE compared to those who did not have PsO (1.4% vs. 1.2%). 445 patients (1.4%) were diagnosed with a DVT or PE with a p-value of < 0.001 compared to those who did not have psoriasis 85,135 (1.2%). An association with patients who died while in the hospital was found with 1.9% of patients with PsO died when compared with those without PsO. Conclusion: Psoriasis patients were also noted to have an increased length of hospitalization than the control group. Other factors such as race and socioeconomic factors were also found to have an association with the development with VTEs.
