Synthesis of Pyrazole and Thiophene Derivatives Together with their Antitumor Evaluations Pages 69-79
Rafat Milad Mohareba, Eman M. Samirb and Elham Ezz El-Arabb
aChemistry Department, Faculty of Science, Cairo University, Giza, Egypt; bNational Organization For Drug Control & Research, P.O. Box 29,Cairo, Egypt
DOI: http://dx.doi.org/10.12970/2308-8044.2015.03.02.3
Download PDFAbstract: The reaction of cyclohexanone, cyanoacetylhydrazine and elemental sulfur gave the 4,5,6,7-tetrahydrobenzo[b]thiophene derivative 3. The latter compound was used as the key starting material for the synthesis of pyrazoles, thiazole derivatives. The newly synthesized products were screening against the three cancer cell lines namely the human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) and the human normal cell line the normal fibroblast WI 38. The results showed that compounds 7a and 19c were the most potent compounds among the tested compounds.
Keywords: Pyrazole, thiophene, tetrahydrobenzo[b]thiophene, cytotoxicity.
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