Plexiform Angiomyxoid Myofibroblastic Tumor: A Rare Mesenchymal Neoplasm Pages 1-4

Mistafa Hafid1, Christopher G. Gibson1 and Jeffrey K. Yenchar2

1Department of Internal Medicine, Fairfield Medical Center, Lancaster, Ohio, USA; 2General Surgical Associates, Lancaster, Ohio, USA

https://doi.org/10.12970/2308-6483.2020.08.01

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Abstract: Plexiform angiomyxoid myofibroblastic tumor of the stomach is a unique mesenchymal tumor that was first described in 2007. The tumor is very rare, and to date, only 18 cases confirmed by immunohistochemistry have been reported in the literature. Representative clinical symptoms are ulceration hematemesis, and anemia. The tumors were mostly located at the antrum. Grossly, the tumor is red, white, brown, and forms a lobulated submucosal or transmural mass. Microscopically, the tumor is characterized by a plexiform growth pattern, the proliferation of cytologically bland spindle cells, and a myxoid stroma that is rich in small vessels. Differential diagnoses include gastrointestinal stromal tumor and other mesenchymal tumors of the gastrointestinal tract.

Keywords: Mesenchymal Neoplasm. Read more