Role of Protease Activated Receptor in Progression of Liver Disease - A Review (GJGHV4N1A3) - synergy - synergy

Role of Protease Activated Receptor in Progression of Liver Disease – A Review Pages 9-11

Nalini Bansal

Senior Histopathologist, MD, DNB, PDCC SRL Ltd, Fortis Escort Heart Institute Okhla, India

http://dx.doi.org/10.12970/2308-6483.2016.04.01.3

Abstract: Protease activated receptors are G –protein coupled receptors involved in hepatic fibrogenesis. PAR expressed on a number of cells including platelets, endothelial cells, monocytes, dendritic cells and hepatic stellate cells (HSC). They are activated after proteolytic cleavage by thrombin [1-3]. They augment the production of proinflammatory cytokines and profibrotic pathways. We herein review role of PAR in progression of liver disease..

Keywords: Protease activated receptor, thrombin, liver fibrosis. Read more

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