
Role of Protease Activated Receptor in Progression of Liver Disease – A Review Pages 9-11
Nalini Bansal
Senior Histopathologist, MD, DNB, PDCC SRL Ltd, Fortis Escort Heart Institute Okhla, India
http://dx.doi.org/10.12970/2308-6483.2016.04.01.3
Abstract: Protease activated receptors are G –protein coupled receptors involved in hepatic fibrogenesis. PAR expressed on a number of cells including platelets, endothelial cells, monocytes, dendritic cells and hepatic stellate cells (HSC). They are activated after proteolytic cleavage by thrombin [1-3]. They augment the production of proinflammatory cytokines and profibrotic pathways. We herein review role of PAR in progression of liver disease..
Keywords: Protease activated receptor, thrombin, liver fibrosis. Read more