Alexander V. Dreval

A.V. Dreval was born in 1947. He graduated from I.M. Sechenov 1stMoscow Medical Institute majoring in General Medicine and was admitted to residency in endocrinology at the same Institute. On completion of residency, he was admitted to graduate courses at I.M. Sechenov 1st MMI, and in 1974 he defended a dissertation for the degree of Cand.Med. From 1974 to 1988 A.V. Dreval was employed at I.M. Sechenov 1st MMI, initially in the position of Assistant Professor, then Associate Professor of the Endocrinology Department. In 1980, he graduated from M.V.Lomonosov Moscow State University, majoring in applied mathematics and received the qualification of mathematician. In 1990 he defended a dissertation for the degree of Doct.Med. In 1996 he received the title of Professor in Endocrinology. Since 1993 he has been in charge of the Therapeutic Endocrinology Department at MRRCI. Since 1994 he is Head of the Department of Therapeutic and Surgical Endocrinology at DIF MRRCI. Since 1995 he is Chief Endocrinologist of Moscow Region.

Prof. A.V. Dreval is the author of 201 research papers (189 in collaboration), 2 monographs, 4 study manuals, as well as two websites on diabetes. He was the research supervisor of 11 dissertations (2 Doctoral and 9 Candidate’s).

Prof. A.V. Dreval’s main areas of research include: optimization of treatment and diagnostic methods for diabetes and its complications, treatment and prevention of osteoporosis, epidemiological hypothyrosis and its prevention, radioiodine therapy of Basedow’s goiter in young patients, endocrinousophthalmopathy, mathematical modeling of endocrinous systems, IT in medicine, particularly web-projects on diabetes.

A.V. Dreval published a number of leading works on complications of insulin-therapy of diabetes. He was the first in Russia to receive anti-insulin serum in laboratory conditions, which could be used in the radioimmunoassay technique of determining diabetes. He developed new methods of treating severe allergies to insulin-containing pharmaceuticals; he was the first to prove the immune mechanism of insulin lipoatrophy and revealed the pathogenetic role of Class A, M, G & E immunoglobulin balance in the development of allergy to insulin. In 2003, he reported a previously unobserved side effect of insulin therapy of diabetes – mass insulin phobia. He revealed its sources, manifestations and suggested methods for prevention and elimination.

Having received the qualification of a mathematician at M.V. Lomonosov MSU, since 1980, A.V. Dreval has been active in the field of mathematical modeling of insulin therapy of diabetes. He developed a number of genuine diabetes models revealing the key role of the liver in the development of some forms of diabetes. Using a mathematical approach, he suggested a unique method of analyzing the results of intravenous glucose tolerance tests, which provides for determining the production of glucose in the liver under normal conditions and with diabetes mellitus. These unique data allowed establishing a special category of patients, in which the leading mechanism for the development of diabetes is an overproduction of glucose in the liver. Moreover, it is possible to reveal this distortion prior to the increase in the blood sugar level. That is, he discovered the early stage of diabetes prior to the increase of BSL.

A number of A.V. Dreval’s studies are dedicated to dietary therapy of diabetes and developed new approaches to prolongation of the “honeymoon period” of diabetes by means of a special diet, as well as optimum dietary options for a combination of diabetes mellitus and hypertension. Methods for assessment of optimum dietary therapy were developed using the method of indirect calorimetry.

Being a doctor and mathematician, A.V. Dreval has recently been active in the field of Internet technologies, developing specialized diabetology sites for doctors, researchers, and patients with diabetes, and is the undoubted leader in this area in Russia. One of his unique websites, www.diabet.ru, is especially popular among both specialists and patients and has the highest rating among such sites in Russia.

Combining research activities with the office of Chief Endocrinologist of Moscow Region, A.V. Dreval makes all efforts to implement latest scientific achievements in medical practice in the region. While working at MRRCI, practically from scratch, he organized the work in three areas of endocrinology, which are socially significant for the Moscow Region: Diabetes mellitus, Thyroid diseases, and Osteoporosis. Within this effort, he trained a group of researchers who are currently developing these areas in Moscow Region under his supervision.

In collaboration with his staff, A.V. Dreval is working on developing a State Register of diabetes patients in Moscow Region. He carries out work in the Moscow Region on developing and expanding the network of “Schools for Diabetes Patients”, this representing a modern approach to increasing the efficiency of diabetes treatment and prevention of complications. It should be noted that work in the field of Diabetology is carried out within the framework of the Moscow Regional Diabetology Center, established by A.V. Dreval and Regional Program “Diabetes Mellitus”, which he supervises.

For more than 10 years, A.V. Dreval has been the Chief Endocrinologist of Moscow Region, and the Academic Council of MRRCI, as well as the Ministry of Health Care of Moscow Region, has acknowledged his work as very successful.

For purposes of advanced training of medical staff in Moscow Region, in 1995 he organized the Department of Clinical Endocrinology at DIF MRRCI, which he presently heads pro bono. During hiswork period, the department prepared 134 endocrinologists for Moscow Region and provided advanced training for 1806 physicians practicing in Moscow Region.

A.V. Dreval is a member of the specialized Academic Council at the RAMS Endocrinology Center, a member of the expert council under State Program “Diabetes Mellitus”, as well as member of the editorial board of such scientific journals as “Problems of Endocrinology”, “Diabetes Mellitus”, “Osteoporosis” and “Andriatrics”.