
Synthesis, Characterization and Microbial Evaluation of Metal Complexes of Molybdenum with Ofloxacin (Levo (S-form) and Dextro (R-form)) Isomers Pages 1-9
Qadeer K. Panhwar1,2 and Shahabuddin Memon2
1Dr. M. A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan; 2National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan
DOI: http://dx.doi.org/10.12970/2308-8044.2014.02.01.1
Download PDFAbstract: The article describes the interaction of molybdenum with dextrofloxacin and levofloxacin (isomers of ofloxacin) antibiotic drugs. Characterization of compounds was made by UV-Vis, FT–IR, 1H NMR, elemental and thermogravimetric analyses. The green colored Mo–dextrofloxacin and yellow colored Mo–levofloxacin complexes were isolated. After complete characterization, the chemical formulae of the complexes were established as [MoO2(R-Oflox)2] or [MoO2(Dextro)2] and [MoO2(Levo)2] or [MoO2(S-Oflox)2]. The microbial evaluation was made by well diffusion method for both ligands and their metal complexes against two bacterial strains, S. aureus and E. coli. It was observed that the antibacterial action of Mo–dextrofloxacin and Mo-levofloxacin was significantly higher than the dextrofloxacin and levofloxacin alone against S. aureus, while no action was observed against E. coli.
Keywords: Antibacterial, synthesis, levofloxacin, ofloxacin, molybdenum. Read more