Specific Thyroid Markers and Auxiliary Diagnostics in Post Pregnancy Woman, Specific and Non-Specific Hypothyreosis-Like Syndromes Pages 136-149

Andrzej Jan Dyszkiewicz1,2,3, Jolanta Kujawa4 and Piotr Wincierz5

1Laboratory of Biotechnology “LABIOT”, Cieszyn, Poland; 2Higher School of Information Technology, Katowice, Poland; 3Silesian Higher School of Medicine, Katowice, Poland; 4Department of Medical Rehabilitation, Medical University of Lodz, Poland; 5Department of Anaesthetics, Princess Alexandra Hospital, Harlow, Essex

DOI: http://dx.doi.org/10.12970/2310-9971.2014.02.03.5

Abstract: Objective: The signs, symptoms and biochemical criteria in most cases of evident and subclinical hypothyreosis are specific and its diagnosis is rather credible. However, there is a group of patients with goitre, especially post-pregnancy women, where criteria of hypothyreosis are often mistaken.

Design: The classic thyroid tests used (CTT): fT4, fT3, TSH, immunology tests(IT): a-TPO, a-TG, CIC, and computer auxiliary diagnostic tests(ADT): BDI, finger photoplethysmography – in 358 patients, divided into groups O(32),CB(38), PH(36), CD(37), PS(41), SH(32), PC(35), DT(34), DN(35), RH(38).

Intervention: Answering the following question: Are there any differences or similarities between the data of classic thyroid tests and auxiliary diagnostic tests (ADT) in distinguished patient groups.

Results: Patient groups (O, PH, CD,DT), normal thyroid parameters fT3, fT4, TSH, a-TPO, a-TG, CIC, normal profile of ADT (BDI(<15), PT(0,28-0,5), PCT (0,4-0,8)). Patients with hypothyreosis (PS) had normal(a-TPO, a-TG, CIC), increased TSH(7,92), and a different profile of ADT (BDI(24,7), PT(0,66) and PCT(-0,185)). Patients with Hashimoto’s disease (RH) had increased a-TPO, a-TG, CIC, TSH, a decreased concentration of fT3, fT4 and similar (PS) ADT profile. Patients in the groups (CB, PC, DN) showed a trend of insignificantly decreased fT3, fT4, a trend of insignificantly increased (a-TPO, a-TG, CIC) and a similar (PS) ADT profile.

Conclusions: The biochemical criteria among healthy individuals and patients with no thyroid illness (PH, CD, DT) correlated with the ADT characteristic profile. Patients fulfilling biochemical criteria of evident (PS) and inflammatory-dependant hypothyreosis (RH) had a quite different, characteristic ADT profile. The biochemically uncertain groups (CB, PC, DN) had an ADT profile similar to the group with evident hypothyreosis. These promising initial results prove the method to be a valuable auxiliary diagnostic.
Keywords: Thyroid disease, biochemical diagnostics, inflammatory hormone dysfunction, computer auxiliary diagnostics, photoplethysmography cold test, endocrine disruptors. Read more