What is the Role of Cutaneous Lymphocyte Antigen in the Pathogenesis of Behçet’s Disease: A Randomized, Prospective Double-Blinded Study Pages 6-11
Murat Borlu1 Pınar Kulluk1 Demet Kartal Salih1 Levent Çınar1 and Cem Evereklioğlu2
1Erciyes University Faculty of Medicine, Department of Dermatology and Venereology Kayseri, Turkey; 2Erciyes University Faculty of Medicine, Department of Ophthalmology, Kayseri, Turkey
DOI: http://dx.doi.org/10.12970/2310-998X.2016.04.01.2Download PDF
Abstract: Background: Behcet’s Disease (BD) is a chronic systemic vasculitis of unknown etiology. Cutaneous lymphocyte antigen (CLA) has an important role in the migration of T cells into the inflamed skin.
Objective: Our aim was to investigate the relationship between CLA+T cell and clinical activity of BD.
Methods: A total of 80 Behçet patients and 20 healthy controls were involved in this study. BD patients were divided into four groups: ocular group genital ulcer group vessel/skin lesion group, inactive group. 10.000 cells in peripheral blood were used to assess the expression levels of CD3, CD4, CD8, CLA+CD4 and CLA+CD8 in lymphocytes with CLA/FITC clone HECA-452 kit.
Results: Erythrocyte sedimentation rate, C-reactive protein and lymphocyte CLA+CD8 levels were found to be higher, whereas CD4/CD8 and CLA+CD4/CLA+CD8 ratios were found lower in patients with BD when compared to controls.
Conclusions: CLA may be an important finding in the determination of etiopathogenesis, disease activity and prognosis of BD.
Keywords: Behçet’s Disease, CLA, Immunology, Pathogenesis.